{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:41:10Z","timestamp":1764312070571,"version":"3.46.0"},"reference-count":63,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Takotsubo cardiomyopathy is characterized by stress\u2010induced systolic dysfunction of the left ventricle that is largely reversible and not related to coronary ischemia. Patients with Takotsubo cardiomyopathy can often develop concurrent arrhythmias and prolonged QTc interval, which have been shown to contribute to significant morbidity and mortality in prior retrospective studies. Hence, we conducted a comprehensive systematic review and meta\u2010analysis to characterize the risk of atrial arrhythmias, life\u2010threatening arrhythmias, and QTc prolongation on clinical outcomes in patients with Takotsubo cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed and EMBASE databases from inception to April 2024. A total of 13 studies were eligible for data collection across the three subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Atrial and life\u2010threatening arrhythmias in Takotsubo cardiomyopathy have an increased risk of in\u2010hospital mortality and cardiogenic shock, a finding that was not observed in patients with prolonged QTc. Upon univariate analysis of the QTc subgroup, younger age and the presence of ST\u2010Elevation were identified as additional negative prognostic indicators of adverse outcomes in Takotsubo cardiomyopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrates the increased risk of different arrhythmic profiles in Takotsubo cardiomyopathy. Further investigation is needed to identify pathophysiological mechanisms and tailored anti\u2010arrhythmics to improve outcomes in this unique subset of Takotsubo patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70138","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T05:24:46Z","timestamp":1752729886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic relevance of arrhythmic and\n                    <scp>QTc<\/scp>\n                    burden in takotsubo cardiomyopathy: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"41","author":[{"given":"Ankit","family":"Hanmandlu","sequence":"first","affiliation":[{"name":"Wayne State University\/Detroit Medical Center Department of Internal Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyothik","family":"Varun Inampudi","sequence":"additional","affiliation":[{"name":"Wayne State University\/Detroit Medical Center Department of Internal Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Hamza","sequence":"additional","affiliation":[{"name":"Guthrie Medical Group  Cortland New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakash","family":"Upreti","sequence":"additional","affiliation":[{"name":"Sands\u2010Constellation Heart Institute Rochester Regional Health  Rochester New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Rasheed","family":"Bahar","sequence":"additional","affiliation":[{"name":"Wayne State University\/Detroit Medical Center Department of Internal Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jawad","family":"Basit","sequence":"additional","affiliation":[{"name":"Department of Medicine Rawalpindi Medical University  Rawalpindi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sivaram","family":"Neppala","sequence":"additional","affiliation":[{"name":"UT Health Science Center at San Antonio  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himaja Dutt","family":"Chigurupati","sequence":"additional","affiliation":[{"name":"New York Medical College at Saint Michael's Medical Center  Newark New Jersey USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rohit","family":"Goru","sequence":"additional","affiliation":[{"name":"Wayne State University School of Medicine  Detroit Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7874-4566","authenticated-orcid":false,"given":"M. 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