{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:41:02Z","timestamp":1764312062816,"version":"3.46.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The relationship between baseline total cholesterol, low\u2010density lipoprotein (LDL), high\u2010density lipoprotein (HDL) and cardiovascular outcomes is well established, but their trajectories over time in elderly Asian patients with atrial fibrillation (AF) remain unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Using the Taipei Medical University Clinical Research Database from 2013 to 2020, we identified 823 AF patients aged above 75 with at least three annual lipid profile measurements. We used an accelerated failure time (AFT) model to examine the association of trajectories with the primary outcome of composite cardiovascular events (stroke, TIA, myocardial infarction, heart failure hospitalization and cardiovascular death).<\/jats:p>\n                    <jats:p>\n                      During follow\u2010up, 308 patients developed events (61.33 per 100 person\u2010years). Three total cholesterol trajectory groups were identified: low (group 1), decreasing (group 2), and middle (group 3). Compared with group 1, individuals in group 3 exhibited a significantly longer event\u2010free survival, with a mean increase of 2.74\u2009years (95% confidence interval [CI]: 1.05\u20137.12;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0394).\n                    <\/jats:p>\n                    <jats:p>\n                      For LDL trajectories, group 3 was associated with a mean increase of 2.35\u2009years (95% CI: 1.11\u20134.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0252) in survival time from the primary outcome compared to group 1. Regarding HDL, participants in group 3\u2014characterized by persistently higher HDL levels\u2014had a 2.12\u2010year longer survival time (95% CI: 1.01\u20134.43;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0456) compared to those in group 1. Triglyceride trajectories showed no significant association with the primary outcome.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this hospital\u2010based cohort study, total cholesterol, LDL, and HDL trajectories are associated with composite cardiovascular outcomes in elderly Asian AF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70151","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T07:30:46Z","timestamp":1753687846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trajectories of Lipid Profile Changes and Cardiovascular Outcomes in Elderly Asian Patients With Atrial Fibrillation"],"prefix":"10.1002","volume":"41","author":[{"given":"Yu\u2010Ting","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Taipei Municipal Wan Fang Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hsuan Joni","family":"Shao","sequence":"additional","affiliation":[{"name":"Graduate Institute of Biomedical Informatics, College of Medical Science and Technology Taipei Medical University  Taipei Taiwan"},{"name":"Clinical Big Data Research Center Taipei Medical University Hospital  Taipei Taiwan"},{"name":"Health Data Analytics and Statistics Center, Office of Data Science Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Chieh","family":"Huang","sequence":"additional","affiliation":[{"name":"Health Data Analytics and Statistics Center, Office of Data Science Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u2010Hsin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Taipei Municipal Wan Fang Hospital Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Danish Center for Health Services Research, Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2838-6596","authenticated-orcid":false,"given":"Jong\u2010Shiuan","family":"Yeh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine Taipei Municipal Wan\u2010Fang Hospital  Taipei Taiwan"},{"name":"Division of Cardiology, Department of Internal Medicine, School of Medicine, College of Medicine Taipei Medical University  Taipei Taiwan"},{"name":"Taipei Heart Institute Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehae177"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000375"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.119.012771"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad615"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021\u20109681(87)90171\u20108"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/strokeaha.115.012004"},{"key":"e_1_2_10_9_1","first-page":"19","article-title":"Management of Dyslipidaemia in the Elderly","volume":"19","author":"Stoll F.","year":"2020","journal-title":"European Society of Cardiology"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1530\/ec\u201023\u20100142"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahjo.2023.100315"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.116.07683"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/circoutcomes.119.005918"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k1453"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/hypertensionaha.117.10106"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102278\u20108769"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102269\u20101123"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0905561"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009638"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1310907"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2018.4635"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028753"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0296413"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154\u2010022\u201009713\u20100"}],"container-title":["Journal of Arrhythmia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/joa3.70151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:37:28Z","timestamp":1764311848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/joa3.70151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,28]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/joa3.70151"],"URL":"https:\/\/doi.org\/10.1002\/joa3.70151","archive":["Portico"],"relation":{},"ISSN":["1880-4276","1883-2148"],"issn-type":[{"type":"print","value":"1880-4276"},{"type":"electronic","value":"1883-2148"}],"subject":[],"published":{"date-parts":[[2025,7,28]]},"assertion":[{"value":"2025-03-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70151"}}