{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T09:00:12Z","timestamp":1767085212842,"version":"3.46.0"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ventricular arrhythmias are prevalent among heart failure with reduced ejection fraction (HFrEF) patients. Rapid rate non\u2010sustained ventricular tachycardia (RR\u2010NSVT) and sustained ventricular tachycardia (VT) can be detected on implantable cardioverter\u2010defibrillator (ICD) interrogation due to discrimination algorithms that differentiate supra\u2010ventricular from ventricular tachycardia. This study aims to assess the incidence of RR\u2010NSVT and sustained VT on ICD interrogation and their correlation with HFrEF guideline\u2010directed medical therapy (GDMT) compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Design<\/jats:italic>\n                      Cross\u2010sectional, analytical study.\n                      <jats:italic>Setting<\/jats:italic>\n                      Heart rhythm device clinic, Electrophysiology department, National Institute of Cardiovascular Diseases (NICVD), Karachi, Pakistan.\n                      <jats:italic>Participants<\/jats:italic>\n                      Patients implanted with dual chamber ICD or cardiac resynchronization therapy defibrillator (CRT\u2010D), aged 18\u2009years or above with HFrEF.\n                      <jats:italic>Outcome Measure<\/jats:italic>\n                      Covariates included demographics, comorbidities, medications, GDMT compliance, and cardiac rhythm device parameters. Incidence of RR\u2010NSVT, sustained VT, and their correlation with HFrEF GDMT compliance was assessed using multivariate logistic regression.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Study evaluated 139 patients. Men 77.7%. The mean age was 56.4\u2009\u00b1\u200913.9\u2009years. The mean LV ejection fraction was 26.4%\u2009\u00b1\u20095.5%. 109 (78.4%) were GDMT compliant (94.3% on beta\u2010blockers, 93.5% on renin\u2010angiotensin inhibitors, 71.9% on aldosterone antagonists, and 15.8% on SGLT\u20102 inhibitors). RR\u2010NSVT episodes were observed in 54 (38.8%) patients, out of whom 37 had RR\u2010NSVT despite GDMT compliance, although this correlation was not statistically significant. Twelve (8.6%) patients had sustained VT, which was significantly less common with GDMT compliance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>More than one\u2010third of participants had RR\u2010NSVT episodes despite HFrEF GDMT compliance. These patients also had associated sustained VT episodes, the occurrence of which was significantly less with GDMT compliance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70156","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T07:04:03Z","timestamp":1754463843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incidence of Rapid Rate Non\u2010Sustained and Sustained Ventricular Tachycardia in Implantable Cardioverter\u2010Defibrillator Recipients and Its Correlation With Heart Failure Guideline\u2010Directed Medical Therapy Compliance"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-3652","authenticated-orcid":false,"given":"Muhammad Taha","family":"Khan","sequence":"first","affiliation":[{"name":"Heart Rhythm Services QE II Health Sciences Center  Halifax Nova Scotia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0379-6000","authenticated-orcid":false,"given":"Ghazala","family":"Irfan","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology National Institute of Cardiovascular Diseases (NICVD)  Karachi Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarim","family":"Ansari","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology National Institute of Cardiovascular Diseases (NICVD)  Karachi Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair","family":"Mumtaz","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology National Institute of Cardiovascular Diseases (NICVD)  Karachi Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Qadir","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology National Institute of Cardiovascular Diseases (NICVD)  Karachi Sindh Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azam","family":"Shafquat","sequence":"additional","affiliation":[{"name":"Cardiac Electrophysiology National Institute of Cardiovascular Diseases (NICVD)  Karachi Sindh 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