{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T09:55:29Z","timestamp":1776851729970,"version":"3.51.2"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs), initially designed to treat diabetes mellitus (DM), have demonstrated the potential to mitigate obesity\u2010related cardiovascular risks. However, their effect on arrhythmias is not well established with limited literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to assess the efficacy of GLP\u20101 RAs and the risk of cardiac arrest and arrhythmias in obese patients based on real\u2010world evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The TriNetX Global Collaborative Network research database was used to identify obese patients aged \u2265\u200918\u2009years from January 2020 to December 2022. Patients were categorized into two groups, one with GLP\u20101 RAs and a control group without GLP\u20101 RAs. After propensity score matching (PSM), relative risk (RR) was used to compare outcomes over follow\u2010up periods of 1\u2009year and 3\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 1:1 PSM, the study cohort comprised 342\u2009753 patients in both groups. The study population had a mean age of 56.35\u2009years. PSM analysis at 1\u2009year follow\u2010up showed that the GLP\u20101 RAs group of patients had a significantly lower risk of cardiac arrest (RR, 0.33 (95% CI: 0.31\u20130.37),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), atrial fibrillation\/flutter (RR, 0.63 (95% CI: 0.60\u20130.66),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), ventricular fibrillation (RR, 0.45 (95% CI: 0.38\u20130.53),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), ventricular tachycardia (RR, 0.56 (95% CI: 0.52\u20130.60),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), second\u2010degree atrioventricular (AV) block (RR, 0.72 (95% CI: 0.63\u20130.82),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), and complete heart block (RR, 0.62 (95% CI: 0.55\u20130.70),\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) when compared with the control group. Similar trends were observed for the 3\u2010year follow\u2010up as well.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study suggests that GLP\u20101 RAs use among obese patients was associated with lower risk of arrhythmias at both 1\u2010year and 3\u2010year follow\u2010ups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70242","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:54:35Z","timestamp":1765806875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association Between Glucagon\u2010Like Peptide\u20101 Receptor Agonists and Risk of Arrhythmias"],"prefix":"10.1002","volume":"41","author":[{"given":"Vikash","family":"Jaiswal","sequence":"first","affiliation":[{"name":"Independent Researcher  Jaunpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Hanif","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8062-5657","authenticated-orcid":false,"given":"Aman","family":"Goyal","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juveriya","family":"Yasmeen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Saint Joseph Hospital  Chicago Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vamsi","family":"Garimella","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Miami  Miami Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusra","family":"Mashkoor","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dow University of Health Sciences  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roopeessh","family":"Vempati","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Trinnity Health Oakland Hospital  Pontiac Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Novonil","family":"Deb","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine North Bengal Medical College and Hospital  Siliguri India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusra Minahil","family":"Nasir","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University of Oklahoma Health Sciences Center  Oklahoma City USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kripa","family":"Rajak","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0681-3825","authenticated-orcid":false,"given":"Abhigan Babu","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Patan Academy of Health Sciences  Lalitpur Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jishanth","family":"Mattumpuram","sequence":"additional","affiliation":[{"name":"Division of Cardiology University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine SUNY Upstate Medical University  Syracuse New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Handbook of Eating and Drinking","author":"Lim H. 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