{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:18:36Z","timestamp":1791242316422,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:00:00Z","timestamp":1771459200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) prevalence has increased with Japan's aging population. Data on cryoballoon ablation (CBA) for persistent AF (PsAF) in Japan is limited. This study reports CBA clinical outcomes in PsAF patients in Japan from the prospective Cryo Global Registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data was analyzed from 60 Japanese centers with 1226 PsAF patients that underwent CBA. The primary endpoints were serious adverse events and freedom from atrial arrhythmia (AA) recurrence, at 12\u2009months. The effect of ablation strategy (pulmonary vein isolation [PVI] or PVI with additional ablations [PVI+]) was evaluated. Quality\u2010of\u2010life (QoL) was measured by EQ\u20105D\u20103L questionnaire.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The patient mean age was 68\u2009\u00b1\u200910\u2009years and 29.0% were female. The overall 12\u2010months Kaplan\u2013Meier (KM) estimate for freedom from AA recurrence was 84.4% (95% CI: 82.2%\u201386.3%). Among PVI+ patients, 33.0% received cavotricuspid isthmus (CTI) and 34.6% received non\u2010CTI ablation (majority being left\u2010atrial roofline [27.2%]). The 12\u2010months KM estimate for freedom from AA recurrence was higher for PVI+ subgroup (86.6% [CI: 83.6%\u201389.1%]) than PVI subgroup (82.0% [CI: 78.6%\u201384.9%]) (HR adj\u2009=\u20091.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025). Twenty\u2010two serious adverse events were reported in 1.6% patients. At 12\u2009months, compared to baseline, QoL improved with a mean summary\u2010index score difference of 0.03\u2009\u00b1\u20090.16 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) and a mean EQ visual analogue scale score difference of 7.9\u2009\u00b1\u200918.5 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study showed CBA is safe and effective for PsAF treatment in real\u2010world use in Japan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      Cryo Global Registry,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      ID NCT02752737\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70291","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:14:33Z","timestamp":1771564473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cryoballoon Ablation for Persistent Atrial Fibrillation in Japan: Cryo Global Registry 12\u2010Months Results"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-5151","authenticated-orcid":false,"given":"Hiroshi","family":"Fukunaga","sequence":"first","affiliation":[{"name":"Sakakibara Heart Institute  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-1707","authenticated-orcid":false,"given":"Masato","family":"Murakami","sequence":"additional","affiliation":[{"name":"Shonan Kamakura General Hospital  Kamakura Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiko","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Inaba","sequence":"additional","affiliation":[{"name":"Japanese Red Cross Saitama Hospital  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiharu","family":"Miura","sequence":"additional","affiliation":[{"name":"Hiroshima Prefectural Hospital  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4661-2999","authenticated-orcid":false,"given":"Yasuteru","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Japan Red Cross Yokohama City Bay Hospital  Yokohama Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4587-9031","authenticated-orcid":false,"given":"Satoshi","family":"Shizuta","sequence":"additional","affiliation":[{"name":"Kyoto University Hospital  Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7774-7477","authenticated-orcid":false,"given":"Atsuhiko","family":"Yagishita","sequence":"additional","affiliation":[{"name":"Tokai University  Hiratsuka Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2507-5565","authenticated-orcid":false,"given":"Koichiro","family":"Kumagai","sequence":"additional","affiliation":[{"name":"Fukuoka Sanno Hospital  Fukuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6388-4398","authenticated-orcid":false,"given":"Shiro","family":"Nakahara","sequence":"additional","affiliation":[{"name":"Dokkyo Medical University Saitama Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9728-6524","authenticated-orcid":false,"given":"Yasuyuki","family":"Egami","sequence":"additional","affiliation":[{"name":"Osaka Rosai Hospital  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4943-1018","authenticated-orcid":false,"given":"Neha","family":"Sawhney","sequence":"additional","affiliation":[{"name":"Medtronic, Inc.  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