{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:48:16Z","timestamp":1782715696638,"version":"3.54.5"},"reference-count":57,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Progressive cardiac conduction disease (PCCD) is a rare inheritable cardiac conduction system disease that may lead to complete heart block, syncope, or sudden cardiac death. The estimated incidence of PCCD is 0.0005%\/year. Recent advances in genetics have revealed a wide variety of diseases associated with the development of PCCD. Ion channel genes (\n                    <jats:italic>SCN5A, KCNK17, TRPM4, HCN4<\/jats:italic>\n                    ), gap junction genes (\n                    <jats:italic>GJA5<\/jats:italic>\n                    ,\n                    <jats:italic>GJC1<\/jats:italic>\n                    ), genes associated with myopathy (\n                    <jats:italic>LMNA<\/jats:italic>\n                    ,\n                    <jats:italic>EMD<\/jats:italic>\n                    ,\n                    <jats:italic>DES<\/jats:italic>\n                    ,\n                    <jats:italic>DMD<\/jats:italic>\n                    ,\n                    <jats:italic>TNNI3K<\/jats:italic>\n                    ,\n                    <jats:italic>DMPK, ZNF9<\/jats:italic>\n                    ), transcription factor genes (\n                    <jats:italic>NKX2\u20105<\/jats:italic>\n                    ,\n                    <jats:italic>TBX5<\/jats:italic>\n                    ), genes associated with metabolic disease (\n                    <jats:italic>PRKAG2<\/jats:italic>\n                    ,\n                    <jats:italic>LAMP2<\/jats:italic>\n                    ,\n                    <jats:italic>GLA<\/jats:italic>\n                    ), and mitochondrial gene variants have all been associated with the occurrence of PCCD. Pacemaker implantation is the first\u2010line therapy for PCCD, but implantable cardioverter defibrillator implantation should be considered in some cases. This review aims to provide a clinically relevant overview of these different forms, with emphasis on their genetic basis and phenotypic expression. We propose a practical classification distinguishing isolated and associated forms of PCCD and discuss the implications for diagnosis, risk stratification, and patient management.\n                  <\/jats:p>","DOI":"10.1002\/joa3.70383","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T12:21:22Z","timestamp":1782390082000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Current Topics of Progressive Cardiac Conduction Disease"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7094-6772","authenticated-orcid":false,"given":"Naokata","family":"Sumitomo","sequence":"first","affiliation":[{"name":"Department of Pediatric Cardiology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1172-2995","authenticated-orcid":false,"given":"Hitoshi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Cardiology Saitama Medical University International Medical Center  Saitama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9219-6152","authenticated-orcid":false,"given":"Takashi","family":"Kumamoto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Saga University  Saga Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine Kagoshima University  Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-1097","authenticated-orcid":false,"given":"Akiko","family":"Seki","sequence":"additional","affiliation":[{"name":"Department of Cardiology Tokyo Women's Medical University  Tokyo Japan"},{"name":"Department of Preventive Medicine Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-672X","authenticated-orcid":false,"given":"Naomasa","family":"Makita","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sapporo Teishinkai Hospital  Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9578-9475","authenticated-orcid":false,"given":"Jean\u2010Jacques","family":"Schott","sequence":"additional","affiliation":[{"name":"Nantes Universit\u00e9 CNRS, INSERM, L'institut du Thorax  Nantes France"},{"name":"ERN GUARD\u2010Heart  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-0852","authenticated-orcid":false,"given":"Arthur A. 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