{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:03:47Z","timestamp":1791295427707,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Obstructive sleep apnea syndrome (OSAS) is common in atrial fibrillation (AF) and may influence AF phenotype and post\u2010ablation recurrence. We aimed to determine whether documented OSAS identifies a distinct clinical phenotype and whether it is associated with post\u2010ablation rhythm\u2010related outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a single\u2010center observational study with two overlapping cohorts. The principal registry cohort comprised 2559 patients with first AF ablation with pulmonary vein isolation (PVI) treated between November\/2021 and July\/2025. Its primary endpoint was the same\u2010center rhythm\u2010intervention endpoint, defined as the first post\u2010index repeat PVI or electrical cardioversion at the study center. A 7\u2010day Holter was scheduled 90\u2009days after ablation. The nested active 2022 cohort comprised 666 AF\/PVI patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Documented OSAS was present in 268 of 2559 registry patients, 10.5%, and in 66 of 652 patients with known OSAS status in the active subset, 10.1%. Documented OSAS was associated with higher BMI, more obesity, hypertension, diabetes, persistent AF, higher triglycerides and liver enzymes, and lower HDL cholesterol. In the registry cohort, the same\u2010center rhythm\u2010intervention endpoint occurred in 59\/268 patients with documented OSAS (22.0%) and 521\/2291 without documented OSAS (22.7%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.788). Documented OSAS was not associated with the registry endpoint after adjustment (OR: 0.87, 95% CI: 0.63\u20131.21;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.411). In the active 2022 cohort, recurrence occurred in 16\/32 patients with documented OSAS (50.0%) and 167\/302 without documented OSAS (55.3%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.581). Adjusted Cox analysis also showed no independent documented OSAS (HR: 1.08, 95% CI: 0.61\u20131.94;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.786).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Documented OSAS identified an adverse cardiometabolic AF ablation phenotype but was not independently associated with same\u2010center rhythm interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70410","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T07:39:14Z","timestamp":1782805154000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Documented Obstructive Sleep Apnea, Cardiometabolic Phenotype, and Rhythm\u2010Related Outcomes After Atrial Fibrillation Ablation: An Observational Cohort Study"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3932-2106","authenticated-orcid":false,"given":"Yazan","family":"Mohsen","sequence":"first","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore MD USA"},{"name":"Department of Cardiology, Electrophysiology and Rhythmology Krankenhaus Porz Am Rhein  Cologne Germany"},{"name":"Department of Cardiology, Faculty of Health School of Medicine, University Witten\/Herdecke  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iryna","family":"Novikov","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Electrophysiology and Rhythmology Krankenhaus Porz Am Rhein  Cologne Germany"},{"name":"Department of Cardiology, Faculty of Health School of Medicine, University Witten\/Herdecke  Witten Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreeram","family":"Sabareesan","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0204-3613","authenticated-orcid":false,"given":"Kensuke","family":"Sakata","sequence":"additional","affiliation":[{"name":"Alliance for Cardiovascular Diagnostic and Treatment Innovation Johns Hopkins University  Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Knitter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Electrophysiology and Rhythmology Krankenhaus Porz Am Rhein  Cologne Germany"},{"name":"Department of Cardiology, Faculty of Health School of Medicine, University Witten\/Herdecke  Witten 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Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4374-7476","authenticated-orcid":false,"given":"Ibrahim","family":"Antoun","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Hospitals of Leicester NHS Trust, Glenfield Hospital  Leicester UK"},{"name":"Division of Cardiovascular Sciences College of Life Sciences, University of Leicester, Glenfield Hospital  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"St\u00f6ckigt","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Electrophysiology and Rhythmology Krankenhaus Porz Am Rhein  Cologne Germany"},{"name":"Department of Internal Medicine II University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"e_1_2_11_2_1","article-title":"Atrial Fibrillation Inpatient 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