{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:03:47Z","timestamp":1791295427727,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is prevalent in cardiac amyloidosis (CA) and is associated with adverse clinical outcomes. Catheter ablation is increasingly used for rhythm control in this population, yet its clinical outcomes remain uncertain. We performed a systematic review and meta\u2010analysis to evaluate arrhythmia recurrence and clinical outcomes following catheter ablation compared with medical therapy in patients with CA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched MEDLINE, Embase, and Scopus from inception through December 2025 for studies evaluating catheter ablation of atrial arrhythmias in CA. Cohort studies reporting arrhythmia recurrence and\/or clinical outcomes were included. The primary outcome was freedom from atrial arrhythmia (AA) following ablation. Secondary outcomes included all\u2010cause mortality, heart failure hospitalization, and stroke. Random\u2010effects models were used to pool event rates and odds ratios (ORs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen observational studies comprising 797 patients with CA and AF were included. The pooled rate of freedom from AA following catheter ablation was approximately 50% (95% CI 37%\u201363%; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200971.7%). The all\u2010cause mortality analysis included 4 observational studies comprising 616 patients. Catheter ablation was associated with lower odds of all\u2010cause mortality (OR 0.26, 95% CI 0.11\u20130.60; I\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u200918.4%); however, this association should be interpreted with caution given the retrospective design and risk of bias. No statistically significant differences were observed for heart failure hospitalization or stroke.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with CA, catheter ablation was associated with modest arrhythmia\u2010free survival and lower odds of all\u2010cause mortality. However, all contributing studies were observational cohorts. Randomized studies are needed to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70441","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T12:50:21Z","timestamp":1786452621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Catheter Ablation for Atrial Fibrillation in Cardiac Amyloidosis: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-3338-1193","authenticated-orcid":false,"given":"Adivitch","family":"Sripusanapan","sequence":"first","affiliation":[{"name":"Department of Medicine, John A.Burns School of Medicine University of Hawaii  Honolulu Hawaii USA"},{"name":"Department of Cardiovascular Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3231-8705","authenticated-orcid":false,"given":"Natee","family":"Deepan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Chulalongkorn University, King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8903-1403","authenticated-orcid":false,"given":"Bheem","family":"Pongsukvechkul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Thammasat University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suphatcha","family":"Kittiwongsopon","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Siriraj Hospital Mahidol University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Choon","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-5854","authenticated-orcid":false,"given":"Pattara","family":"Rattanawong","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Phoenix Arizona USA"},{"name":"Sport and Genetic Electrophysiology Clinic Pali Momi Heart Center, Pali Momi Medical Center, Hawaii Pacific Health  Aiea Hawaii USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1976-6420","authenticated-orcid":false,"given":"Dan","family":"Sorajja","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win\u2010Kuang","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4463-7447","authenticated-orcid":false,"given":"Ronpichai","family":"Chokesuwattanaskul","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine Chulalongkorn University, King Chulalongkorn Memorial Hospital  Bangkok Thailand"},{"name":"Center of Excellence in Arrhythmia Research Cardiac Center, King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narut","family":"Prasitlumkum","sequence":"additional","affiliation":[{"name":"Sport and Genetic Electrophysiology Clinic Pali Momi Heart Center, Pali Momi Medical Center, Hawaii Pacific Health  Aiea Hawaii 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