{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:03:47Z","timestamp":1791295427668,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T00:00:00Z","timestamp":1786233600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cardiac resynchronization therapy (CRT) improves outcomes in patients with heart failure and left bundle branch block (LBBB); however, many patients remain non\u2010responders. Identifying effective electrical resynchronization early remains an important clinical need.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the association between resolution of V5\u2013V6 R\u2010wave notching\/slurring during left ventricular\u2010only pacing (LV\u2010only pacing), combined with an LV\u2010only pacing percentage \u2265\u200950% at 1\u2009month, and early left ventricular reverse remodeling in patients with complete LBBB (CLBBB) undergoing CRT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively studied 49 patients with CLBBB who underwent CRT. Patients with resolution of V5\u2013V6 R\u2010wave notching\/slurring during LV\u2010only pacing at implantation and an LV\u2010only pacing percentage \u2265\u200950% at 1\u2009month were classified as the R\u2010Notch Resolution group; all others were classified as the Non\u2013R\u2010Notch Resolution group. The primary endpoint was left ventricular reverse remodeling at 1\u2009month, defined as a \u2265\u200915% reduction in left ventricular end\u2010systolic volume (LVESV) from baseline. Logistic regression analysis was performed to identify associated factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifteen patients were classified into the R\u2010Notch Resolution group and 34 into the Non\u2013R\u2010Notch Resolution group. One\u2010month left ventricular reverse remodeling occurred more frequently in the R\u2010Notch Resolution group (80.0% vs. 47.1%). In multivariable logistic regression analysis, R\u2010Notch Resolution group status remained independently associated with 1\u2010month left ventricular reverse remodeling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Resolution of V5\u2013V6 R\u2010wave notching\/slurring during LV\u2010only pacing, combined with an LV\u2010only pacing percentage \u2265\u200950% at 1\u2009month, was independently associated with early left ventricular reverse remodeling after CRT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70443","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T06:27:27Z","timestamp":1786343247000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of\n                    <scp>QRS<\/scp>\n                    Notch Resolution During\n                    <scp>LV<\/scp>\n                    \u2010Only Fusion Pacing With Early Left Ventricular Reverse Remodeling After Cardiac Resynchronization Therapy"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-1396","authenticated-orcid":false,"given":"Junji","family":"Morita","sequence":"first","affiliation":[{"name":"Department of Cardiology Sapporo Cardiovascular Clinic  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-5725","authenticated-orcid":false,"given":"Yuhei","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sapporo Cardiovascular Clinic  Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumetsugu","family":"Munakata","sequence":"additional","affiliation":[{"name":"Department of Clinical Technology Sapporo Cardiovascular Clinic  Sapporo Hokkaido 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