{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:07:43Z","timestamp":1789016863950,"version":"build-2803163510"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004046","name":"Karen Elise Jensens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["3165\u201000295B"],"award-info":[{"award-number":["3165\u201000295B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n The prognostic significance of device\u2010detected atrial high\u2010rate episodes (AHRE) in patients with implantable cardioverter defibrillator (ICD) remains poorly understood. We aimed to evaluate whether device\u2010detected AHRE \u2265\u20096\u2009min is temporally associated with appropriate ICD therapy and cardiac hospitalization.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We studied consecutive patients with dual chamber or cardiac resynchronization therapy ICD with predominantly sinus rhythm and followed with remote monitoring (RM). Risk of ICD therapy and hospitalization was compared inside a 60\u2010day peri\u2010AHRE period (from 30\u2009days before to 30\u2009days after AHRE detection) with risk outside the peri\u2010AHRE period. We included appropriate ICD therapies only. Adjusted extended Cox model with time\u2010varying exposure analysis was used to assess potential associations between AHRE and ICD therapies and hospitalization.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n We included 882 patients. Median age 67\u2009years [interquartile range; 59\u201373], 81% male, 76% had coronary artery disease, and 61% CRT\u2010D. The 30\u2010day risk of appropriate ICD shock was 0.8% inside the peri\u2010AHRE period compared with 0.2% outside the peri\u2010AHRE period (adjusted hazard ratio [aHR] 3.04; 95% confidence interval [CI]: 1.67\u20135.52;\n p<\/jats:italic>\n \u2009<\u20090.001). The 30\u2010day risk of any appropriate ICD therapy was increased inside compared with outside the peri\u2010AHRE period (1.2% vs. 0.4%, aHR 1.71 [95% CI: 1.14\u20132.57],\n p<\/jats:italic>\n \u2009=\u20090.01). Cardiac hospitalization was higher inside the peri\u2010AHRE period (3.1% vs. 1.0%, aHR 1.42 [95% CI: 1.05\u20131.92],\n p<\/jats:italic>\n \u2009=\u20090.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The risk of appropriate ICD shock is three\u2010fold elevated during a 60\u2010day period surrounding AHRE detection. A comparable temporal pattern was noted for cardiac hospitalizations, supporting that AHREs may indicate clinical worsening of heart disease.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/joa3.70448","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T04:21:11Z","timestamp":1789014071000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Risks of Appropriate Implantable Cardioverter Defibrillator Therapy and Hospitalization Are Increased Around Device\u2010Detected Atrial High\u2010Rate Episodes Longer Than 6\u2009min"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5841-3438","authenticated-orcid":false,"given":"Nanna","family":"N\u00f8rgaard","sequence":"first","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"},{"name":"Department of Public Health Aarhus University Aarhus C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-4624","authenticated-orcid":false,"given":"Christoffer Tobias","family":"Witt","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1672-222X","authenticated-orcid":false,"given":"Mads Brix","family":"Kronborg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9414-1653","authenticated-orcid":false,"given":"Jens Cosedis","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Aarhus University Hospital Aarhus N Denmark"},{"name":"Department of Clinical Medicine Aarhus University Aarhus N Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/01.STR.32.2.392","article-title":"Characteristics, Outcome, and Care of Stroke Associated With Atrial Fibrillation in Europe: Data From a Multicenter Multinational Hospital\u2010Based Registry (The European Community Stroke Project)","volume":"32","author":"Lamassa M.","year":"2001","journal-title":"Stroke"},{"issue":"18","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of Diagnosed Atrial Fibrillation in Adults: National Implications for Rhythm Management and Stroke Prevention: The AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study","volume":"285","author":"Go A. 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