{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:54:36Z","timestamp":1791982476693,"version":"4.4.0"},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Arrhythmia"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glucagon\u2010like peptide\u20101 receptor agonists (GLP\u20101 RAs) reduce cardiovascular risk in obesity, but their effect on atrial fibrillation (AF) in heart failure with preserved ejection fraction (HFpEF) remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We analyzed TriNetX data comparing obese, non\u2010diabetic HFpEF patients treated with GLP\u20101 RAs (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009478) with untreated patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096887). Propensity matching yielded 470 patients per cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      GLP\u20101 RA therapy was not associated with reduced AF incidence (HR 0.86; 95% CI, 0.53\u20131.39;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.543) but was associated with lower mortality (HR 0.42; 95% CI, 0.23\u20130.75;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GLP\u20101 RAs may not reduce AF incidence in obese, HFpEF patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/joa3.70455","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:20:00Z","timestamp":1790061600000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon\u2010Like Peptide\u20101 Agonists and the Incidence of Atrial Fibrillation in Obese Patients With Heart Failure With Preserved Ejection Fraction and No Diabetes"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2909-562X","authenticated-orcid":false,"given":"Farah","family":"Rassam","sequence":"first","affiliation":[{"name":"Medicine Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6831-9912","authenticated-orcid":false,"given":"Esteban Kosak","family":"Lopez","sequence":"additional","affiliation":[{"name":"Medicine Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Sass","sequence":"additional","affiliation":[{"name":"Medicine Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6672-649X","authenticated-orcid":false,"given":"Thitiphan","family":"Srikulmontri","sequence":"additional","affiliation":[{"name":"Medicine Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8494-1765","authenticated-orcid":false,"given":"Evan","family":"Isaacs","sequence":"additional","affiliation":[{"name":"Medicine Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Malin","sequence":"additional","affiliation":[{"name":"Medicine Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0086-5269","authenticated-orcid":false,"given":"Phuuwadith","family":"Wattanachayakul","sequence":"additional","affiliation":[{"name":"Medicine Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olayinka","family":"Afolabi\u2010Brown","sequence":"additional","affiliation":[{"name":"Cardiology Department Jefferson Einstein Philadelphia Hospital  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.01.049"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12113682"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.08.048"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2410027"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2306963"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2307563"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201059616\u20102"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.08.021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2025.156463"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.70085"}],"container-title":["Journal 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