{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:43:19Z","timestamp":1791348199263,"version":"4.3.1"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Basic Microbiol."],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Genistein, a radioprotective soy isoflavone and protein kinase inhibitor, blocks the invasion of pathogenic bacteria in mammalian epithelial cells. The purpose of this study was to evaluate the direct effect of genistein on the survival and growth of the probiotic\n                    <jats:italic>Lactobacillus reuteri<\/jats:italic>\n                    and selected opportunistic bacteria\n                    <jats:italic>in vitro<\/jats:italic>\n                    as a prelude to\n                    <jats:italic>in vivo<\/jats:italic>\n                    use for managing postirradiation sepsis. We evaluated the opportunistic bacterial enteropathogens\n                    <jats:italic>Escherichia coli<\/jats:italic>\n                    ,\n                    <jats:italic>Shigella sonnei<\/jats:italic>\n                    , and\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    as well as\n                    <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    and the non\u2010pathogenic organism,\n                    <jats:italic>Bacillus anthracis<\/jats:italic>\n                    (Sterne). The latter two bacteria are found in the environment and may be of concern in irradiated individuals. A standard\n                    <jats:italic>in vitro<\/jats:italic>\n                    test was employed to evaluate the direct effect of genistein on the bacteria. This test involved determining bacterial colony forming unit (CFU) counts at a single concentration of genistein. In the CFU assays, significant reductions in CFUs were found for\n                    <jats:italic>S. aureus<\/jats:italic>\n                    and\n                    <jats:italic>B. anthracis<\/jats:italic>\n                    when cultured in the presence of 100 \u03bcM genistein. However,\n                    <jats:italic>L. reuteri<\/jats:italic>\n                    ,\n                    <jats:italic>E. coli<\/jats:italic>\n                    ,\n                    <jats:italic>S. sonnei<\/jats:italic>\n                    , and\n                    <jats:italic>K. pneumoniae<\/jats:italic>\n                    were not altered by\n                    <jats:italic>in vitro<\/jats:italic>\n                    culturing in the presence of 100 \u03bcM genistein. These results demonstrate the\n                    <jats:italic>in vitro<\/jats:italic>\n                    antimicrobial activity of genistein. Furthermore, the use of genistein in combination with probiotics may augment the effectiveness of antimicrobial therapies currently used in the management of infections, including those induced by ionizing irradiation. (\u00a9 2006 WILEY\u2010VCH Verlag GmbH &amp; Co. KGaA, Weinheim)\n                  <\/jats:p>","DOI":"10.1002\/jobm.200510073","type":"journal-article","created":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T11:18:57Z","timestamp":1153135137000},"page":"329-335","source":"Crossref","is-referenced-by-count":121,"title":["Antibacterial activity of the soy isoflavone genistein"],"prefix":"10.1002","volume":"46","author":[{"given":"Hyunki","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Landauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Foriska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. David","family":"Ledney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.6.G1280"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1128\/iai.62.5.2021-2026.1994","article-title":"Factors affecting invasion of HT\u201029 and HEp\u20102 epithelial cells by organisms of the Mycobacterium avium complex","volume":"62","author":"Bermudez L. E.","year":"1994","journal-title":"Infect. 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