{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T18:59:02Z","timestamp":1761418742006},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T00:00:00Z","timestamp":1311206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Basic Microbiol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>40\u2010<jats:italic>O<\/jats:italic> \u2010[2\u2010Hydroxyethyl]rapamycin (RAD), a novel derivative of the immunosuppressive drug rapamycin, was analyzed for its immunomodulatory influence during the interaction of human monocyte\u2010derived dendritic cells (moDC) with <jats:italic>Aspergillus fumigatus<\/jats:italic>. RAD is clinically used to prevent graft\u2010<jats:italic>versus<\/jats:italic> \u2010host disease as well as solid organ and bone marrow transplant rejection. However, it may constitute a risk factor for the development of opportunistic infections, such as invasive aspergillosis which is mainly caused by the most common airborne fungal pathogen <jats:italic>A. fumigatus<\/jats:italic>. moDC were generated in the presence or absence of RAD. In this setting, RAD had various modulating effects on the immune function of DC. A decrease of pro\u2010 and anti\u2010inflammatory cytokines (IL\u201012, TNF\u2010\u03b1, CCL20, IL\u201010) was observed. Furthermore, RAD reduced the expression of innate immunity receptors (TLR2, TLR4, dectin\u20101), impaired the maturation capacity of moDC observed through the reduction of costimulatory factors (CD40, CD80, CD83, CD86), and impaired their capacity to phagocytose and damage<jats:italic> A. fumigatus<\/jats:italic>. These data demonstrate that RAD influences the differentiation of DC. RAD modulates the cytokine response of DC to <jats:italic>A. fumigatus<\/jats:italic> and reduces their ability to kill germ tubes. Thus, RAD treatment might affect the risk of invasive aspergillosis independently of its capacity of blocking T cell activation. (\u00a9 2012 WILEY\u2010VCH Verlag GmbH &amp; Co. KGaA, Weinheim)<\/jats:p>","DOI":"10.1002\/jobm.201100071","type":"journal-article","created":{"date-parts":[[2011,7,21]],"date-time":"2011-07-21T08:35:21Z","timestamp":1311237321000},"page":"269-276","source":"Crossref","is-referenced-by-count":3,"title":["40\u2010<i>O<\/i> \u2010[2\u2010Hydroxyethyl]rapamycin modulates human dendritic cell function during exposure to <i>Aspergillus fumigatus<\/i>"],"prefix":"10.1002","volume":"52","author":[{"given":"Ruth","family":"Bauer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Mezger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Blockhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna\u2010Lena","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Kurzai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Einsele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juergen","family":"Loeffler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,7,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.28.721"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(98)00045-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199707150-00008"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.30.10.1044"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.2.310"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2009.07.002"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.6.3034-3042.2003"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.3.1362"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/528694"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.3.1084"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3370"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000235438.11132.8f"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000235433.03554.4f"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01618-07"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2008.06.009"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.14.0988"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1688"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.3.1480-1489.2006"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.2144\/97221pf02"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1999.4461"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00267-07"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.249"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2546"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.7018"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0290OC"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2008.01.025"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0b013e3181b0e608"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.171.9.4569"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200301150-00025"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.389"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/175.1.222"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2009.130"}],"container-title":["Journal of Basic Microbiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjobm.201100071","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jobm.201100071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T09:02:20Z","timestamp":1700557340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jobm.201100071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7,21]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1002\/jobm.201100071"],"URL":"https:\/\/doi.org\/10.1002\/jobm.201100071","archive":["Portico"],"relation":{},"ISSN":["0233-111X","1521-4028"],"issn-type":[{"value":"0233-111X","type":"print"},{"value":"1521-4028","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,7,21]]}}}