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Growth of the organisms was significantly effected in both solid and liquid media at different test compound concentrations. The minimum inhibitory concentrations (MICs) of Isoeugenol (compound 1) against 31 strains of <jats:italic>Candida<\/jats:italic> ranged 100\u2013250 \u03bcg\/ml and those of <jats:italic>o<\/jats:italic> \u2010methoxy cinnamaldehyde (compound 2) ranged 200\u2013500 \u03bcg\/ml, respectively. Insight studies to mechanism suggested that these compounds exert antifungal activity by targeting H<jats:sup>+<\/jats:sup>\u2010ATPase located in the membranes of pathogenic <jats:italic>Candida<\/jats:italic> species. At their respective MIC<jats:sub>90<\/jats:sub> average inhibition of H<jats:sup>+<\/jats:sup>\u2010efflux for standard, clinical and resistant isolates caused by compound 1 and compound 2 was 70%, 74%, 82% and 42%, 42% and 43%. Respective inhibition of H<jats:sup>+<\/jats:sup>\u2010efflux by fluconazole (5 \u03bcg\/ml) was 94%, 92% and 10%. Inhibition of H<jats:sup>+<\/jats:sup>\u2010ATPase leads to intracellular acidification and cell death. SEM analysis of <jats:italic>Candida<\/jats:italic> cells showed cell membrane breakage and alterations in morphology. Haemolytic activity on human erythrocytes was studied to exclude the possibility of further associated cytotoxicity. (\u00a9 2012 WILEY\u2010VCH Verlag GmbH &amp; Co. KGaA, Weinheim)<\/jats:p>","DOI":"10.1002\/jobm.201100272","type":"journal-article","created":{"date-parts":[[2011,12,5]],"date-time":"2011-12-05T15:40:42Z","timestamp":1323099642000},"page":"504-512","source":"Crossref","is-referenced-by-count":26,"title":["Proton pumping ATPase mediated fungicidal activity of two essential oil components"],"prefix":"10.1002","volume":"52","author":[{"given":"Rimple","family":"Bhatia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheikh","family":"Shreaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelofar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumathi","family":"Muralidhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seemi F","family":"Basir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhat","family":"Manzoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luqman A","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,5]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2010.07.020"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2009.10.001"},{"issue":"65","key":"e_1_2_1_4_2","first-page":"1472","article-title":"Liquid and vapour\u2010phase antifungal activities of selected essential oils against Candida albicans: microscopic observations and chemical characterization of cymbopogon citrates","volume":"10","author":"Amit K.T.","year":"2010","journal-title":"BMC. 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