{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T05:05:03Z","timestamp":1791003903256,"version":"4.1.0"},"reference-count":38,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Basic Microbiol."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Carbapenem\u2010resistant <jats:italic>Acinetobacter baumannii<\/jats:italic> has been known as an opportunistic pathogen that causes a variety of illness worldwide. In this study, we characterize the molecular epidemiology of 174 non\u2010repetitive clinical isolates of <jats:italic>A. baumannii<\/jats:italic> collected from January to June 2009 from Xiangya Hospital, in Hunan Province, China, including an outbreak period of A. <jats:italic>baumannii<\/jats:italic>. These 174 isolates harbored <jats:italic>A. baumannii<\/jats:italic> intrinsic gene OXA\u201051. They were resistant to multiple antibiotics with resistance rates as 49.4% to imipenem, 48.3% to meropenem, 46.6% to ampicillin\u2010sulbactam, 6.9% to cefoperazone\u2010sulbactam, and 6.3% to minocycline. 74 out of 174 isolates were identified as carbapenemase\u2010producing strains, among which bla<jats:sub>OXA\u201023<\/jats:sub> gene was found in 71 isolates. These 74 carbapenemase expression strains could be divided into four genotypes by enterobacterial repetitive intergenic consensus (ERIC)\u2010PCR, with 19, 17, 33 and 5 clones in each group. We also found four imipenem resistant isolates carrying OXA\u201023 gene without showing carbapenemase phenotype. Our findings show that the bla<jats:sub>OXA\u201023<\/jats:sub> gene is the common carbapenemase gene among carbapenem\u2010resistant <jats:italic>Acinetobacter<\/jats:italic> spp. isolates, suggesting that clonal spread of carbapenemase\u2010producing isolates may be one important factor which results in the high carbapenem resistance rate in the local hospital in Hunan Province, China.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jobm.201100420","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T08:54:53Z","timestamp":1336985693000},"page":"121-127","source":"Crossref","is-referenced-by-count":13,"title":["Molecular epidemiology of carbapenem\u2010resistant <i>Acinetobacter<\/i> spp. from XiangYa Hospital, in Hunan Province, China"],"prefix":"10.1002","volume":"53","author":[{"given":"Zhenhua","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijuan","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Xiangya Hospital of Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.2.583-588.2001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00796-06"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.008904-0"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1128\/JCM.38.9.3299-3305.2000","article-title":"Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem\u2010hydrolyzing enzyme: high\u2010level carbapenem resistance in A. baumannii is not due solely to the presence of beta\u2010lactamases","volume":"38","author":"Bou G.","year":"2000","journal-title":"J. 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