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The present study demonstrates for the first time the eco\u2010friendly biosynthesis of CdS NPs using the yeast <jats:italic>Trichosporon jirovecii<\/jats:italic>. The biosynthesis of CdS NPs were confirmed by UV\u2010Vis spectrum and characterized by X\u2010ray diffraction assay and electron microscopy. Scanning and transmission electron microscope analyses shows the formation of spherical CdS NPs with a size range of about 6\u201315\u2009nm with a mean Cd:S molar ratio of 1.0:0.98. <jats:italic>T. jirovecii<\/jats:italic> produced hydrogen sulfide on cysteine containing medium confirmed by positive cysteine\u2010desulfhydrase activity and the colony color turned yellow on 0.1\u2009mM cadmium containing medium. <jats:italic>T. jirovecii<\/jats:italic> tolerance to cadmium was increased by the UV treatment and three 0.6\u2009mM cadmium tolerant mutants were generated upon the UV radiation treatment. The overall results indicated that <jats:italic>T. jirovecii<\/jats:italic> could tolerate cadmium toxicity by its conversion into CdS NPs on cysteine containing medium using cysteine\u2010desulfhydrase as a defense response mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jobm.201500275","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T10:43:42Z","timestamp":1444905822000},"page":"520-530","source":"Crossref","is-referenced-by-count":41,"title":["<i>Trichosporon jirovecii<\/i>\u2013mediated synthesis of cadmium sulfide nanoparticles"],"prefix":"10.1002","volume":"56","author":[{"given":"Ashraf Farag","family":"El\u2010Baz","sequence":"first","affiliation":[{"name":"Department of Industrial Biotechnology Genetic Engineering and Biotechnology Research Institute University of Sadat City Sadat City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noha Mohamed","family":"Sorour","sequence":"additional","affiliation":[{"name":"Department of Industrial Biotechnology Genetic Engineering and Biotechnology Research Institute University of Sadat City Sadat City Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youssria Mohamed","family":"Shetaia","sequence":"additional","affiliation":[{"name":"Department of Microbiology Faculty of Science Ain Shams University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Biosynthesis of noble metal nanoparticles and their application","volume":"4","author":"Verma V.C.","year":"2009","journal-title":"Nutr. 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