{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:49:16Z","timestamp":1791560956439,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pooria moulavi"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Basic Microbiol"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Silver nanoparticles (AgNPs) are at the forefront of the swiftly developing scope of nanotechnology. In the current study, we investigated the green synthesis of AgNPs using <jats:italic>Artemisia scoporia<\/jats:italic> as a reducing and capping agent. The biosynthesized AgNPs were characterized using ultraviolet\u2013visible spectroscopy, X\u2010ray diffraction, Fourier\u2010Transform infrared spectroscopy, dispersive absorption spectroscopy, scanning electron microscopy, and transmission electron microscopy. The efficacy of the nanoparticle synthesis was assessed by comparing the antibiofilm activity with commercial AgNPs. The effect of sub\u2010minimum inhibitory concentrations (MICs) of AgNPs on biofilm formation was determined by microtiter plate assay. The expression level of the <jats:italic>icaA<\/jats:italic> and <jats:italic>icaR<\/jats:italic> genes was assessed by real\u2010time polymerase chain reaction assay. The structural and functional aspects of AgNPs were confirmed. The expression levels of <jats:italic>icaA<\/jats:italic> and <jats:italic>icaR<\/jats:italic> in the isolates exposed to sub\u2010MIC of both commercial and biosynthetic AgNPs were lower and higher than in the control group, respectively. Our results also indicated that greater reduction and induction in <jats:italic>icaA<\/jats:italic> and <jats:italic>icaR<\/jats:italic> gene expression were noticed with the sub\u2010MIC doses of biosynthetic AgNP versus commercial AgNP, respectively. This study suggested the application of AgNPs as a significant therapeutic and clinical option in the future and usage for fabricating medical implants. Nevertheless, further investigation is required for examining the pharmaceutical and medicinal properties of AgNPs.<\/jats:p>","DOI":"10.1002\/jobm.201900096","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T11:49:29Z","timestamp":1556538569000},"page":"701-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Antibiofilm effect of green engineered silver nanoparticles fabricated from <i>Artemisia scoporia<\/i> extract on the expression of <i>icaA<\/i> and <i>icaR<\/i> genes against multidrug\u2010resistant <i>Staphylococcus aureus<\/i>"],"prefix":"10.1002","volume":"59","author":[{"given":"Pooria","family":"Moulavi","sequence":"first","affiliation":[{"name":"Department of Biology, Tehran North Branch Islamic Azad University Tehran 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