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The genome analysis with various bioinformatics tools revealed that the causative pathogen (SARS\u2010CoV\u20102) belongs to the subgenus\n                    <jats:italic>Sarbecovirus<\/jats:italic>\n                    of the genus\n                    <jats:italic>Betacoronavirus<\/jats:italic>\n                    , with highly similar genome as bat coronavirus and receptor\u2010binding domain (RBD) of spike glycoprotein as Malayan pangolin coronavirus. Based on its genetic proximity, SARS\u2010CoV\u20102 is likely to have originated from bat\u2010derived CoV and transmitted to humans via an unknown intermediate mammalian host, probably Malayan pangolin. Further, spike protein S1\/S2 cleavage site of SARS\u2010CoV\u20102 has acquired polybasic furin cleavage site which is absent in bat and pangolin suggesting natural selection either in an animal host before zoonotic transfer or in humans following zoonotic transfer. In the current review, we recapitulate a preliminary opinion about the disease, origin and life cycle of SARS\u2010CoV\u20102, roles of virus proteins in pathogenesis, commonalities, and differences between different corona viruses. Moreover, the crystal structures of SARS\u2010CoV\u20102 proteins with unique characteristics differentiating it from other CoVs are discussed. Our review also provides comprehensive information on the molecular aspects of SARS\u2010CoV\u20102 including secondary structures in the genome and protein\u2013protein interactions which can be useful to understand the aggressive spread of the SARS\u2010CoV\u20102. The mutations and the haplotypes reported in the SARS\u2010CoV\u20102 genome are summarized to understand the virus evolution.\n                  <\/jats:p>","DOI":"10.1002\/jobm.202000537","type":"journal-article","created":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T10:02:35Z","timestamp":1610964155000},"page":"180-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":163,"title":["SARS\u2010CoV\u20102, the pandemic coronavirus: Molecular and structural insights"],"prefix":"10.1002","volume":"61","author":[{"given":"Swapnil B.","family":"Kadam","sequence":"first","affiliation":[{"name":"Department of Botany Savitribai Phule Pune University Pune India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetika S.","family":"Sukhramani","sequence":"additional","affiliation":[{"name":"Department of Botany Savitribai Phule Pune University Pune 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India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.03.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0118-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00108-019-00671-5"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001017"},{"key":"e_1_2_11_6_1","article-title":"The species and its viruses\u2014a statement of the coronavirus study group","author":"Gorbalenya 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