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Enhanced drug dosages have effects such as toxicity, drug\u2013drug interactions, and increased drug resistance by fungi. This article reviews the current state\u2010of\u2010the\u2010art of antifungals, structure, mechanism of action, other usages, and toxic side effects. The emergence of nanoformulations to transport and uniformly release cargo at the target site is a boon in antifungal treatment. The article details research that lead to the development of nanoformulations of antifungals and potential advantages and avoidance of the lacunae characterizing conventional drugs. A range of nanoformulations based on liposomes, polymers are in various stages of research and their potential advantages have been brought out. It could be observed that under similar dosages, test models, and duration, nanoformulations provided enhanced activity, reduced toxicity, higher uptake and higher immunostimulatory effects. 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In the years to come, robust methods for the preparation of nanoformulations taking into account the repeatability and reproducibility in action, furthering the studies on nanoformulation toxicity and studies of human models are required before extensive use of nanoformulations as a prescribed drug.<\/jats:p>","DOI":"10.1002\/jobm.202100204","type":"journal-article","created":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T11:05:25Z","timestamp":1628161525000},"page":"849-873","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Potent antifungal agents and use of nanocarriers to improve delivery to the infected site: A systematic review"],"prefix":"10.1002","volume":"61","author":[{"given":"Saraswathi","family":"Nagaraj","sequence":"first","affiliation":[{"name":"Faculty of Allied Health Sciences, Chettinad Hospital and Research Institute Chettinad Academy of Research and Education  Chennai Tamilnadu 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