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The commercially available naphthoyl chloride and 4\u2010bromoaniline were condensed in dry dichloromethane (DCM) in the presence of Et<jats:sub>3<\/jats:sub>N to form <jats:italic>N<\/jats:italic>\u2010(4\u2010bromophenyl)\u20101\u2010naphthamide (86%) (<jats:bold>3<\/jats:bold>). Using a Pd(0) catalyzed Suzuki\u2013Miyaura Cross\u2010Coupling reaction of (<jats:bold>3<\/jats:bold>) and various boronic acids, a series of <jats:italic>N<\/jats:italic>\u2010([1,1\u02b9\u2010biaryl]\u20104\u2010yl)\u20101\u2010naphthamide derivatives (<jats:bold>4a\u2013h<\/jats:bold>) were synthesized in moderate to good yields. The synthesized derivatives were evaluated for cytotoxicity haemolytic assay and biofilm inhibition activity through in silico and in vitro studies. Molecular docking, ADME (absorption, distribution, metabolism, and excretion), toxicity risk, and other cheminformatics predict synthesized molecules as biologically active moieties, further validated through in vitro studies in which compounds (<jats:bold>4c<\/jats:bold>) and (<jats:bold>4f<\/jats:bold>) showed significant haemolytic activity whereas (<jats:bold>4e<\/jats:bold>) exhibited an efficient biofilm inhibition activity against Gram\u2010negative bacteria <jats:italic>Escherichia coli<\/jats:italic> and Gram\u2010positive bacteria <jats:italic>Bacillus subtilis<\/jats:italic>. When forming biofilms, bacteria become resistant to various antimicrobial treatments. Currently, research is focused on the development of agents that inhibit biofilm formation, thus the present work is valuable for preventing future drug resistance.<\/jats:p>","DOI":"10.1002\/jobm.202100288","type":"journal-article","created":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T12:57:49Z","timestamp":1635771469000},"page":"1143-1155","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<i>N<\/i>\u2010([1,1\u02b9\u2010biaryl]\u20104\u2010yl)\u20101\u2010naphthamide\u2010based scaffolds synthesis, their cheminformatics analyses, and screening as bacterial biofilm inhibitor"],"prefix":"10.1002","volume":"62","author":[{"given":"Saba","family":"Ejaz","sequence":"first","affiliation":[{"name":"Department of Chemistry, Government College University of Faisalabad  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Zubair","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government College University of Faisalabad  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasir","family":"Rasool","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government College University of Faisalabad  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faiz","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government College University of Faisalabad  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Bilal","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government College University of Faisalabad  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulraiz","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Government College University of Faisalabad  Faisalabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8018-5890","authenticated-orcid":false,"given":"Ataf A.","family":"Altaf","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Okara  Okara Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed A. 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