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Chloroquine serves as a drug of choice, with primaquine as a radical cure. However, with the appearance of resistance to chloroquine and treatment has been shifted to artemisinin combination therapy followed by primaquine as a radical cure. Sulphadoxine\u2010pyrimethamine, mefloquine, and atovaquone\u2010proguanil are other drugs of choice in chloroquine\u2010resistant areas, and later resistance was soon reported for these drugs also. The emergence of drug resistance serves as a major hurdle to controlling and eliminating malaria. The discovery of robust molecular markers and regular surveillance for the presence of mutations in malaria\u2010endemic areas would serve as a helpful tool to combat drug resistance. Here, in this review, we will discuss the endemicity of <jats:italic>P. vivax<\/jats:italic>, a historical overview of antimalarial drugs, the appearance of drug resistance and molecular markers with their global distribution along with different measures taken to reduce malaria burden due to <jats:italic>P. vivax<\/jats:italic> infection and their resistance.<\/jats:p>","DOI":"10.1002\/jobm.202200316","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T12:32:54Z","timestamp":1663677174000},"page":"1417-1428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Global scenario of <i>Plasmodium vivax<\/i> occurrence and resistance pattern"],"prefix":"10.1002","volume":"62","author":[{"given":"Davinder","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-4973","authenticated-orcid":false,"given":"Rakesh","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,20]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World malaria report 2020: 20 years of global progress and challenges. 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