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Alzheimer's disease (AD) is pathologically characterized by senile plaques comprising beta\u2010amyloid and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau as a microtubule\u2010associated protein with a key role in the pathogenesis of AD. Periodontitis through inflammatory pathways is a risk factor for deteriorating cognitive impairment in AD patients. Poor oral hygiene coupled with immunocompromised status in older adults causes periodontal diseases and chronic inflammations through an oral bacterial imbalance. Toxic bacterial products, including bacteria themselves, can reach the central nervous system through the bloodstream and evoke inflammatory responses. 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