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Despite its widespread application, there is limited understanding of how cyanobacteria, which play vital ecological roles in aquatic systems, respond to such chemical stressors. This study addresses this gap by investigating the physiological and metabolic responses of the cyanobacterium\n                    <jats:italic>Anabaena laxa<\/jats:italic>\n                    to rac\u2010metalaxyl exposure. Cultures were treated with 100\u2009mg\/L and 200\u2009mg\/L concentrations of the fungicide. Results showed increased intracellular accumulation of rac\u2010metalaxyl at 200\u2009mg\/L, leading to significant reductions in cell growth, photosynthetic pigments, and the activities of key enzymes such as phosphoenolpyruvate carboxylase and ribulose\u20101,5\u2010bisphosphate carboxylase\/oxygenase. Further elevated lipid peroxidation levels indicated oxidative damage. Consequently, rac\u2010metalaxyl triggered substantial metabolic shifts, total soluble sugars increased by 7.66% at 100\u2009mg\/L and 67.48% at 200\u2009mg\/L; malic acid rose to 76.23% at 200\u2009mg\/L; amino acids increased by 27.14% at 100\u2009mg\/L and 48.8% at 200\u2009mg\/L; total fatty acids rose by 10.11% at 100\u2009mg\/L and 35.06% at 200\u2009mg\/L. These findings suggest that\n                    <jats:italic>Anabaena laxa<\/jats:italic>\n                    exhibits coordinated oxidative and metabolic responses to mitigate rac\u2010metalaxyl toxicity, highlighting its potential resilience and role in the bioremediation of contaminated aquatic environments.\n                  <\/jats:p>","DOI":"10.1002\/jobm.70073","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T01:49:04Z","timestamp":1750729744000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Physiological and Molecular Responses of\n                    <i>Anabaena laxa<\/i>\n                    to Rac\u2010Metalaxyl Fungicide: Exploring Metabolic and Oxidative Changes"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5171-7592","authenticated-orcid":false,"given":"Wael A.","family":"Fathy","sequence":"first","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad A.","family":"Alsherif","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shereen M.","family":"Korany","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Princess Nourah bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abeer S.","family":"Aloufi","sequence":"additional","affiliation":[{"name":"Department of Biology, College of Science Princess Nourah bint Abdulrahman University  Riyadh Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samy","family":"Selim","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences Jouf University Sakaka Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira M.","family":"Shaban","sequence":"additional","affiliation":[{"name":"Botany and Microbiology Department, Faculty of Science Beni\u2010Suef University Beni\u2010Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,23]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"181","article-title":"The Potential Applications of Cyanobacteria (Blue\u2010Green Algae): A Brief Review","volume":"4","author":"Sadanand V. 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