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Various mechanisms have been implicated to explain the AMR, like the circulation of the plasmid carrying antibiotic resistance genes (ARG), mutation in target genes (intrinsic and plasmid), overexpression of efflux pumps, underexpression of porins, etc. Various therapeutic strategies used to combat AMR exist, such as nonantibiotic approaches (vaccinations or immunotherapy, nano\u2010derived treatments, and bacteriophage therapy), Anti\u2010plasmid and plasmid curing approaches, combinatorial approaches (combination of antibiotics as well as a combination of two different approaches), and plant\u2010based therapeutics. In this focused review, we have discussed the potential use of bacteriophage\u2010based therapy to combat AMR and biofilm formation through multifaceted ways, including lysis of the drug\u2010resistant bacteria, targeting the pili of AMR plasmids conjugation systems, and use of phage\u2010derived lytic proteins. Phages can also be used to decontaminate surfaces in healthcare settings, prevent bacterial contamination in food (meat and dairy), and control bacterial populations in environmental settings, such as water and soil. 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