{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T08:20:07Z","timestamp":1787818807777,"version":"build-2784847793"},"reference-count":72,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Basic Microbiology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Endophytes of\n                    <jats:italic>Panax ginseng<\/jats:italic>\n                    are symbiotic microbes colonizing internal tissues asymptomatically, forming a core component of the ginseng microecosystem through co\u2010evolution. This review summarizes recent progress on ginseng endophytes, covering community diversity, ecological functions, and application prospects. Culturable endophytic fungi span over 40 genera, dominated by Ascomycota, while endophytic bacteria mainly belong to Firmicutes, Proteobacteria and Actinobacteria. Research methodologies have advanced from culture\u2010based isolation to high\u2010throughput amplicon sequencing and ASV\u2010based profiling. Functionally, approximately 78% of culturable isolates produce indole\u20103\u2010acetic acid, and strains with phosphate\u2010solubilizing, nitrogen\u2010fixing and siderophore\u2010secreting activities are widely identified. For biocontrol,\n                    <jats:italic>Paenibacillus<\/jats:italic>\n                    and\n                    <jats:italic>Burkholderia<\/jats:italic>\n                    strains show broad\u2010spectrum antagonism against 5\u20138 common ginseng pathogens, with\n                    <jats:italic>Bacillus<\/jats:italic>\n                    strains achieving 61.45%\u201380% mycelial inhibition. Over 10 endophytic species can synthesize ginsenosides or convert common ginsenosides into rare monomers like Rg2, Rb3, and compound K, with some elicitor strains increasing total ginsenoside contents in adventitious roots up to fourfold. Ginseng endophytes show great potential as microbial fertilizers and biocontrol agents for sustainable ginseng cultivation, biocatalysts for rare ginsenosides production, and sources of novel bioactive lead compounds for drug discovery. Current challenges, including the abundance of unculturable microbiota, unclear host\u2010microbe interactions, and inconsistent field efficacy are discussed, along with future research directions.\n                  <\/jats:p>","DOI":"10.1002\/jobm.70194","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:13:09Z","timestamp":1786356789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Research Progress on the Diversity, Functions, and Applications of Endophytes in\n                    <i>Panax ginseng<\/i>"],"prefix":"10.1002","volume":"66","author":[{"given":"Ying","family":"Yang","sequence":"first","affiliation":[{"name":"School of Biological Engineering Dalian Polytechnic University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xibin","family":"Yue","sequence":"additional","affiliation":[{"name":"School of Biological Engineering Dalian Polytechnic University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5215-5423","authenticated-orcid":false,"given":"Siyu","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Biological Engineering Dalian Polytechnic University Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20240813.102"},{"key":"e_1_2_10_3_1","first-page":"2938","article-title":"Research Progress of Endophyte in Panax ginseng","volume":"24","author":"Fan Z. 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