{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,15]],"date-time":"2024-05-15T05:48:45Z","timestamp":1715752125519},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T00:00:00Z","timestamp":1108598400000},"content-version":"vor","delay-in-days":7718,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To explore the changes in the relationship between skeletal and Ca<jats:sup>2+<\/jats:sup> homeostasis with age, we studied 50 dogs divided into four age groups. The skeletal uptake of <jats:sup>85<\/jats:sup>Sr decreased markedly with age, and the immunoreactive parathyroid hormone (iPTH) level increased. There was a significant correlation between iPTH value and the calculated short\u2010term exchange of Ca in bone (r = \u22120.55; p &lt; 0.001). Bone formation and bone resorption decreased with age except that in the oldest group of dogs the resorption increased (p &lt; 0.001). We suggest that in aging dogs the skeletal exchange of Ca falls to a very low level that decreases the immediate effect of PTH and thus leads to a chronic net increase in circulating PTH. Concomitant with this is an increase in osteoclastic bone resorption and, over a long time, loss of skeletal mass.<\/jats:p>","DOI":"10.1002\/jor.1100020103","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T13:15:04Z","timestamp":1109250904000},"page":"8-14","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Age\u2010related changes in bone in the dog: Calcium homeostasis"],"prefix":"10.1002","volume":"2","author":[{"given":"E. 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