{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T21:46:28Z","timestamp":1763070388120},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":7719,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The excised palmar fascia of 11 patients with Dupuytren's disease was separated clinically into nodules and cords. Myofibroblasts were seen by light and electron microscopy in each of the nodules, but the cords generally lacked myofibroblasts. Only one cord specimen had microscopic features that were intermediate between nodule and cord. Electron microscopy demonstrated that <jats:italic>in vivo<\/jats:italic> differences between myofibroblasts from nodules and fibroblasts from cords and control skin samples could be preserved <jats:italic>in vitro.<\/jats:italic> Growth studies showed slower growth of cultured myofibroblasts (mean \u00b1 SD generation time 68.7 \u00b1 15 h) than cord\u2010derived fibroblasts (mean \u00b1 SD generation time 51.5 \u00b1 0.9 h). These data suggest that the life cycle of the myofibroblasts from Dupuytren's disease nodules differs from that of fibroblasts found in cordlike tissues. These myofibroblasts have biological characteristics nearly identical to those of myofibroblasts found in other contracting tissues, such as granulating wounds and breast cancer.<\/jats:p>","DOI":"10.1002\/jor.1100020305","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T13:18:05Z","timestamp":1109251085000},"page":"247-256","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Dupuytren's disease: Comparative growth dynamics and morphology between cultured myofibroblasts (nodule) and fibroblasts (cord)"],"prefix":"10.1002","volume":"2","author":[{"given":"Jerry S. Vande","family":"Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard H.","family":"Gelberman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duane","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Sicurello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(78)80112-9"},{"key":"e_1_2_1_3_2","first-page":"131","article-title":"Dupuytren's contracture: fibroblast contraction?","volume":"66","author":"Gabbiani G","year":"1972","journal-title":"Am J Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.2106\/00004623-198062030-00012","article-title":"Dupuytren's contracture. An electron microscopic, biochemical and clinical correlative study","volume":"62","author":"Gelberman RH","year":"1980","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-8165(77)80095-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0072-968X(76)90052-8"},{"key":"e_1_2_1_7_2","first-page":"579","article-title":"Growth dynamics of tissue cultured myofibroblasts from granulating wounds","volume":"33","author":"Rudolph R","year":"1982","journal-title":"Surg Forum"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00294930"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198205000-00021"},{"key":"e_1_2_1_10_2","first-page":"187","article-title":"Comparative growth dynamics between cultured myofibroblasts from granulating wounds and dermal fibroblasts","volume":"114","author":"Van de Berg JS","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_1_11_2","first-page":"3","article-title":"Growth dynamics of cultured myofibroblasts from human breast cancer and nonmalignant contracting tissues","volume":"73","author":"Van de Berg JS","year":"1984","journal-title":"Plast Reconstr Surg"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100020305","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100020305","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:18:40Z","timestamp":1697793520000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100020305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/jor.1100020305"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100020305","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]},"assertion":[{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}