{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T16:29:48Z","timestamp":1715531388456},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":7719,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have described a previously unrecognized chondrodystrophy characterized by short\u2010limbed dwarfism, blue sclera, severe cardiopulmonary problems, and failure of postnatal growth. The first of two siblings thus affected died at age 6 months following attempted correction of an atrial septal defect. Growth plate cartilage from multiple sites obtained at autopsy showed a marked abnormality of architecture on the light microscopic level. Biochemical studies demonstrated an absence of normal \u03b1 1(II) collagen in costochondral junction growth plate cartilage and an appearance of the major collagen in a band which comigrates on sodium dodecyl sulfate\u2010polyacrylamide gel electrophoresis with 3\u03b1 collagen. Cartilage extracted from structural rib appeared to be normal.<\/jats:p>","DOI":"10.1002\/jor.1100020406","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T13:18:53Z","timestamp":1109251133000},"page":"339-345","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Abnormality of cartilage collagen in a patient with unclassified chondrodystrophy"],"prefix":"10.1002","volume":"2","author":[{"given":"Michael D.","family":"Sussman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaddeus","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth N.","family":"Rosenbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary","family":"Balian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"7852","article-title":"Human cartilage collagens","volume":"257","author":"Burgeson RE","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(79)80024-8"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.78.12.7745"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.93.3.767"},{"key":"e_1_2_1_6_2","first-page":"46A","article-title":"Abnormal cartilage collagen in thanatophoric dwarfism (Abstract)","volume":"27","author":"Hollister DW","year":"1975","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-8315-8_1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197704000-00939"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80140-7"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/227680a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(71)90006-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi00522a014"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-9068-2_1"},{"key":"e_1_2_1_14_2","first-page":"137","article-title":"Chondro\u2010osseous pathology in the chondrodystrophies","volume":"114","author":"Rimoin DL","year":"1976","journal-title":"Clin Ortho"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"12444","DOI":"10.1016\/S0021-9258(18)33733-5","article-title":"A unique low molecular weigh collagen secreted by cultured chicken embryo chondrocytes","volume":"257","author":"Schmid TM","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"12451","DOI":"10.1016\/S0021-9258(18)33734-7","article-title":"Metabolism of low molecular weight collagen by chondrocytes obtained from histologically distinct zones on the chick embryo tibio\u2010tarsus","volume":"257","author":"Schmid TM","year":"1982","journal-title":"J Biol Chem"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(80)81265-8"},{"key":"e_1_2_1_18_2","first-page":"813","article-title":"Morphologic studies in the skeletal dysplasias","volume":"96","author":"Sillence D","year":"1979","journal-title":"Am J Pathol"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0174-173X(82)80027-7"},{"key":"e_1_2_1_20_2","first-page":"385","article-title":"Pathogenesis of pseudoachondroplasia and diastrophic dysplasia","volume":"104","author":"Stanescu V","year":"1982","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"8887","DOI":"10.1016\/S0021-9258(18)43585-5","article-title":"Evidence for a structural mutation of procollagen type I in a patient with the Ehlers\u2010Danlos syndrome type VII","volume":"255","author":"Steinmann G","year":"1980","journal-title":"J Biol Chem"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100020204"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-333320-9.50009-X"},{"key":"e_1_2_1_24_2","first-page":"6","article-title":"Biochemical analysis of epiphyseal cartilage during growth and in some osteochondrodysplasias","author":"Svejcar J","year":"1975","journal-title":"Original article series"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1982.tb05905.x"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100020406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100020406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T02:32:38Z","timestamp":1697769158000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100020406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/jor.1100020406"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100020406","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]},"assertion":[{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}