{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T19:48:44Z","timestamp":1721764124210},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":7353,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Near\u2010term fetal rat tibiae were grown in M.E.M. Eagle\/NCTC 135\/15% newborn calf serum in 5% carbon dioxide and 5, 10, 21, 35, 60, and 90% oxygen for 3, 7, 10, and 14 days. Linear growth of the explants, as measured from macrophotographs of the explants at day zero and each of the days above, was greastest in the lower oxygen concentrations and least in the days above, was greastest in the lower oxygen concentration and least in the higher oxygen concentrations. Breaking strengths of the tibial diaphyses were signigicantly reduced in those explants grown in 60 and 90% oxygen. When the fetal rat tibiae were grown in 60% oxygen for 7 days and were subjected to a capacitively coupled electrical signal (sine wave, 60 kHz, 10 V peak\u2010to\u2010peak output signal; current density and field in the culture dish calculated to be 5.2 \u03bcA\/ cm<jats:sup>2<\/jats:sup> and 0.32 mV\/cm, respectively), the breaking strengths and middiaphyseal widths were statistically significantly greater than control tibiae grown in 60% oxygen alone. It is concluded that an appropriate capacitively coupled elecmalian long bone model.<\/jats:p>","DOI":"10.1002\/jor.1100030307","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T13:24:05Z","timestamp":1109251445000},"page":"311-320","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Amelioration of oxygen\u2010induced osteoporosis in the in vitro fetal rat tibia with a capacitively coupled electrical field"],"prefix":"10.1002","volume":"3","author":[{"given":"Carl T.","family":"Brighton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Claude E.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"Arangio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-196811000-00006"},{"key":"e_1_2_1_3_2","first-page":"427","volume-title":"Electrical Properties of Bone and Cartilage","author":"Bassett CAL","year":"1979"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820090312"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/204652a0"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.184.4136.575"},{"key":"e_1_2_1_7_2","first-page":"311","volume-title":"Electrical Properties of Bone and Cartilage","author":"Bassett LS","year":"1979"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197503000-00033"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2106\/00004623-197658070-00012","article-title":"In vitro epiphyseal plate growth in various constant electric fields","volume":"58","author":"Brighton CT","year":"1976","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/00003086-198111000-00015","article-title":"Electrically induced osteogenesis: relationships between charge, current density, and the amount of bone formed","volume":"161","author":"Brighton CT","year":"1981","journal-title":"Clin Orthop"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100010106"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2106\/00004623-196951070-00018","article-title":"In vitro epiphyseal\u2010plate growth in various oxygen tensions","volume":"51","author":"Brighton CT","year":"1969","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100020104"},{"key":"e_1_2_1_14_2","first-page":"199","article-title":"Studies on the regeneration of ossal tissue. 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