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When the number of malignancies in these rats was compared with control and sham\u2010operated animals, a small increase in sarcomata was observed in animals bearing metal alloy implants containing high contents of cobalt, chromium, or nickel. An increased incidence of lymphomata with bone involvement was also observed in rats bearing metal implants when compared with control and sham\u2010operated animals.<\/jats:p>","DOI":"10.1002\/jor.1100040311","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:57:40Z","timestamp":1109249860000},"page":"346-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":83,"title":["Malignant neoplasms associated with orthopedic implant materials in rats"],"prefix":"10.1002","volume":"4","author":[{"given":"Vincent A.","family":"Memoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Alroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge 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