{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T04:40:17Z","timestamp":1761021617736},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":6988,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Joint lesions were induced by implantation of a rigid piece of polyethylene sutured under the patella and quadriceps tendon of the rabbit's right knee. Compared to the left sham\u2010operated knee, follow\u2010up studies revealed progressive changes that consisted of early and transient synovial hyperemia and proliferation and late osteoarthritis. By day 7 after surgery, soft synovial\u2010like tissue proliferated around the implant and the articular margins of the femoral trochlea indicating primitive \u201costeophytic\u201d protuberances (synovio\u2010phytes). By day 15 after surgery, the synoviophytes had acquired a more solid consistency and were composed mostly of fibrocartilage covered by a fibro\u2010cellular synovial lining (chondrophytes). By that time, this tissue was invaded with vascular channels; signs of ossification were already present in the deepest layer adjacent to bone. Between the 2nd and 12th weeks, this fibro\u2010cartilaginous tissue, except for the surface fibrous or fibrocartilaginous layer, was progressively replaced by immature bone (osteophyte). Secondary bone remodeling started soon after the first lamellae of immature bone were deposited. Complete integration of the osteophyte into the distal femur occurred during the 2nd and 3rd month.<\/jats:p>","DOI":"10.1002\/jor.1100040404","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:57:49Z","timestamp":1109249869000},"page":"420-426","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Joint reaction to polyethylene implantation: A method for inducing osteoarthritic change and osteophyte formation in the rabbit knee joint"],"prefix":"10.1002","volume":"4","author":[{"given":"Fernando","family":"Garcia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragoslav R.","family":"Mitrovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-68382-4_9"},{"key":"e_1_2_1_3_2","first-page":"145","article-title":"Arthrose experimentale","volume":"49","author":"Arlet J","year":"1982","journal-title":"Rev Rhum"},{"key":"e_1_2_1_4_2","first-page":"409","article-title":"Experimental production of synovitis and marginal articular exostoses in the knee joint of dogs","volume":"37","author":"Chrisman OD","year":"1965","journal-title":"Yale J Biol Med"},{"key":"e_1_2_1_5_2","first-page":"278","article-title":"Induction of osteoarthrosis in the rabbit knee joint","volume":"147","author":"Floman Y","year":"1979","journal-title":"Clin Orthop"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197305000-00026"},{"key":"e_1_2_1_7_2","first-page":"105","volume-title":"The Joints and Synovial Fluid","author":"Ghadially FN","year":"1978"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.1.12"},{"key":"e_1_2_1_9_2","first-page":"996","article-title":"A view on the pathogenesis of osteoarthritis","volume":"29","author":"Howell DS","year":"1978","journal-title":"Bull Rheum Dis"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678208992170"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677008991540"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1302\/0301-620X.57B3.314","article-title":"Osteophytes and the osteoarthritic femoral head","volume":"57","author":"Jeffery AK","year":"1975","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1302\/0301-620X.59B1.576611","article-title":"An experimental model of osteoarthritis: early morphological and biochemical changes","volume":"59","author":"MacDevitt C","year":"1977","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-196901000-00006"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197153080-00008"},{"key":"e_1_2_1_16_2","first-page":"321","article-title":"La r\u00e9action des tissus articulaires \u00e1 la pr\u00e9sence d'un corps \u00e9tranger implant\u00e9 dans le genou du lapin. 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