{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:31:10Z","timestamp":1762673470855},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":6623,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This investigation examines the failure mechanism of bone from patients with osteogenesis imperfecta (OI). Mechanical testing and ultrastructural analysis of surgically obtained bone specimens, from patients with OI and from approximately age matched normal controls, were performed. Small rectangular bone samples (1.0 mm \u00d7 1.2 mm \u00d7 15mm) with a prismatic cross section were put under three\u2010point bending to determine the work to fracture. Furthermore, the fracture surface was observed with scanning electron microscopy (SEM). The SEM observation of partially dissected lamellae was also performed to determine the collagen organization of the bone. The OI bone has a consistently lower work to fracture and reduced collagen organization than the normal controls. The fracture surface of the OI bone is rough and exhibits a \u201cpull\u2010out\u201d type of morpholgy, as opposed to the smoother fracture surface of the controls. This study shows that a relatively simple mechanical test utilizing a small amount of bone can differentiate between a diseased state (OI) and a normal state of bone.<\/jats:p>","DOI":"10.1002\/jor.1100050118","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T13:00:39Z","timestamp":1109250039000},"page":"139-143","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Fracture failure mechanisms in patients with osteogenesis imperfecta"],"prefix":"10.1002","volume":"5","author":[{"given":"Benjamin","family":"Alman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Frasca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00003086-198109000-00010","article-title":"Biochemical abnormalities in osteogenesis imperfecta","volume":"159","author":"Brown D","year":"1981","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.2106\/00004623-197557060-00015","article-title":"The mechanical properties of bone tissue in children","volume":"57","author":"Curry JD","year":"1975","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_4_2","first-page":"97","article-title":"Concepts in collagen biochemistry: Evidence that collagenopathies underlie osteogenesis imperfecta","volume":"159","author":"Eyre DR","year":"1981","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197456040-00012"},{"key":"e_1_2_1_6_2","first-page":"146","article-title":"Micromechanical oscillators and techniques for determining the dynamic moduli of microsamples of human cortical bone at microstrains","volume":"103","author":"Frasca P","year":"1981","journal-title":"J Biomed Eng"},{"key":"e_1_2_1_7_2","first-page":"211","article-title":"A new technique for studying collagen fibers and ground substance in bone with scanning electron microscopy","volume":"80","author":"Frasca P","year":"1978","journal-title":"Micro Acta"},{"key":"e_1_2_1_8_2","first-page":"137","article-title":"The structure and biomechanics of bone","volume":"34","author":"Katz JL","year":"1981","journal-title":"Symp Soc Exp Biol"},{"key":"e_1_2_1_9_2","volume-title":"Strong Solids","author":"Kelly A","year":"1966"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.1658323"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1941.00200050058005"},{"key":"e_1_2_1_12_2","first-page":"1480","volume-title":"Pathologic Basic of Disease","author":"Robbins S","year":"1979"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/00003086-198109000-00004","article-title":"Osteogenesis Imperfecta: An expanding panorama of variants","volume":"159","author":"Sillence D","year":"1981","journal-title":"Clin Orthop Rel Res"},{"key":"e_1_2_1_14_2","volume-title":"The Brittle Bone Syndrome Osteogenesis Imperfecta","author":"Smith R","year":"1983"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00550177"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100050118","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100050118","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T01:27:29Z","timestamp":1697851649000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100050118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/jor.1100050118"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100050118","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]},"assertion":[{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}