{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T04:45:08Z","timestamp":1791521108704,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":6623,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The capacity for functional adaptation within the skeleton was studied using the functionally isolated turkey ulna preparation. The results of this study would suggest that adaptive bone remodeling is extremely sensitive to alterations in both the magnitude and distribution of the strain generated within the bone tissue. At present, it appears that a loading regime can only influence bone remodeling when it is dynamic in nature. The full osteogenic potential of its influence is then achieved after only an extremely short exposure to this stimulus. The potency of the stimulus appears to be proportional to the magnitude of the strain engendered. As strain levels that are acceptable in one location induce adaptive remodeling in others, it would appear that each region of each bone is \u201cgenetically programmed\u201d to accept a particular amount and pattern of intermittent strain as \u201cnormal.\u201d Deviation from this \u201coptimal strain enviroment\u201d will stimulate changes in the bone's remodeling balance, resulting in adaptive increases or decreases in its mass.<\/jats:p>","DOI":"10.1002\/jor.1100050217","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T13:01:36Z","timestamp":1109250096000},"page":"300-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":431,"title":["Osteoregulatory nature of mechanical stimuli: Function as a determinant for adaptive remodeling in bone"],"prefix":"10.1002","volume":"5","author":[{"given":"Clinton T.","family":"Rubin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance E.","family":"Lanyon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"146","article-title":"The prevention of disuse osteoporosis in sedentary rabbits","volume":"9","author":"Burr DB","year":"1984","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(81)90081-6"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(70)90028-X"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(79)90007-1"},{"key":"e_1_2_1_6_2","first-page":"81","volume-title":"Mechanical Properties of Bone","author":"Churches AE","year":"1981"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.34.1.100"},{"key":"e_1_2_1_8_2","first-page":"389","article-title":"Influence of the long\u2010term continous bending on the bone. 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