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Three different theapeutic regimens were used in order to assess the effect of increasing the frequency and of delaying the commencement of administration. The results were assessed by measurement of animal growth rate, clinical condition, bacterial and leukocyte counts in synovial fluid, and histological appearance. An inadequate dosage regimen (a single daily dose) prevented spread of bacteria but did not control abscesses. Delay in commencing treatment permitted persistence and spread of abscesses with destruction of the secondary (epiphyseal) ossification center and even transphyseal spread into metaphyseal bone. Repair by fibroblasts was mainly seen in articular and epiphyseal cartilage but was not seen in the epiphyseal ossification center during the duration of the experiments (up to 18 days). Synovial fluid sampling with measurement of leukocyte and bacterial concentrations appears to be a useful guide to the effectiveness of treatment, because the numbers of cells correlate with the pathological process.<\/jats:p>","DOI":"10.1002\/jor.1100060109","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T13:09:04Z","timestamp":1109250544000},"page":"63-72","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Acute staphylococcal septic arthritis: The effect of cloxacillin therpy in an avian model"],"prefix":"10.1002","volume":"6","author":[{"given":"Harjit","family":"Patel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sydney","family":"Nade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100050213"},{"key":"e_1_2_1_3_2","first-page":"249","article-title":"Treatment and sequelae of experimentally produced septic arthritis","volume":"122","author":"Bardenheier JA","year":"1966","journal-title":"Surg Gynaecol Obstet"},{"key":"e_1_2_1_4_2","first-page":"499","article-title":"A study of the repair of articular cartilage","volume":"8","author":"Bennet GA","year":"1932","journal-title":"Am J Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1975.tb05756.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/6.2.147"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/00313028409084737"},{"key":"e_1_2_1_8_2","volume-title":"Statistical methods for research workers","author":"Fisher RA","year":"1970"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197310000-00021"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(76)90753-1"},{"key":"e_1_2_1_11_2","first-page":"469","volume-title":"Histology","author":"Ham AW","year":"1979"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.247.6.797"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/cpt1972135part1724"},{"key":"e_1_2_1_14_2","first-page":"668","article-title":"Avascular necrosis of the captial epiphysis following osteomyelitis","volume":"56","author":"Kemp HBS","year":"1974","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_15_2","first-page":"121","article-title":"Antibiotic therapy in acute infections of bone and joints in children","volume":"65","author":"Learmonth ID","year":"1984","journal-title":"S Afr Med J"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.247.6.835"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711020102"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-5898(20)30955-X"},{"key":"e_1_2_1_19_2","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1302\/0301-620X.65B3.6841388","article-title":"Acute septic arthritis in infancy and childhood","volume":"65","author":"Nade S","year":"1983","journal-title":"J Bone Joint Surg"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197102182840702"},{"key":"e_1_2_1_21_2","first-page":"423","article-title":"Pediatric osteomyelitis and septic arthritis. 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