{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:06:18Z","timestamp":1778220378968,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":6014,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1988,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Utilizing a sciatic neurectomy model of disuse osteoporosis, the effects on rates of bone formation and bone resorption were examined when a capacitively coupled electrical signal was applied to the denervated tibia in the rat. It was found that a low\u2010voltage, symmetrical sine wave, 60\u2010kHz, capacitively coupled signal had no significant effect on the amount of bone resorption occurring in denervated right tibiae in rats previously labeled with [<jats:sup>3<\/jats:sup>H]tetracycline. This was true whether the signal was applied while osteoporosis was developing (prevention of osteoporosis) or after it had been established (treatment of osteoporosis). If a similar capacitively coupled signal was applied to rats in which osteoporosis was well established, and the rats were labeled with [<jats:sup>3<\/jats:sup>H]tetracycline daily during a 12\u2010day treatment period, it was found that there was statistically significant enhancement of the amount of new bone formation (increased [<jats:sup>3<\/jats:sup>H]tetracycline incorporation) in the tibiae that received the signal as compared with that of the controls. These results indicate that prevention or amelioration of disuse osteoporosis that occurs with a capacitively coupled electrical signal is due not to a change in the rate of bone resorption, but to an increase in the rate of bone formation.<\/jats:p>","DOI":"10.1002\/jor.1100060509","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:46:00Z","timestamp":1109249160000},"page":"676-684","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Treatment of denervation\/disuse osteoporosis in the rat with a capacitively coupled electrical signal: Effects on bone formation and bone resorption"],"prefix":"10.1002","volume":"6","author":[{"given":"Carl T.","family":"Brighton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory T.","family":"Tadduni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R.","family":"Goll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solomon R.","family":"Pollack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-36-5-313"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-068701-5.50012-9"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02008098"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(85)90312-6"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.2106\/00004623-198567070-00005","article-title":"Treatment of sciatic denervation disuse osteoporosis in the rat tibia with capacitive coupled electrical stimulation","volume":"64","author":"Brighton CT","year":"1985","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2106\/00004623-197052060-00006","article-title":"The effect of calcitonin on immobilization osteopenia","volume":"52","author":"Chinoff RT","year":"1970","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02547231"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00003086-198303000-00034","article-title":"The effect of pulsing electromagnetic fields on bone metabolism in experimental disuse osteoporosis","volume":"173","author":"Cruess RL","year":"1983","journal-title":"Clin Orthop"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02196193"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197303000-00032"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02017544"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1302\/0301-620X.36B3.464","article-title":"The nature of bone changes associated with nerve injuries and disuse","volume":"36","author":"Gillespie JA","year":"1954","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196901232800405"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-196811000-00007"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02409500"},{"key":"e_1_2_1_17_2","first-page":"144","article-title":"Metabolism of tetracycline in the rat and the dog","volume":"130","author":"Kelly RG","year":"1960","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100010107"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02279190"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02546415"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1302\/0301-620X.46B4.764","article-title":"The influence on immobilization of bone formation as evaluated by osseous incorporation of tetracyclines","volume":"46","author":"Landry M","year":"1964","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02010345"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02010747"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/ort.1972.43.suppl-144.01"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(68)90037-7"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197107000-00022"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.2106\/00004623-196850040-00005","article-title":"Effect of fluoride on disuse osteoporosis in the cat","volume":"50","author":"Milicic M","year":"1968","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1971.tb00640.x"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1090090806"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02408616"},{"key":"e_1_2_1_31_2","first-page":"240","article-title":"The use and possible misuse of tetracycline as a vital stain","volume":"140","author":"Treharne RW","year":"1979","journal-title":"Clin Orthop"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198108133050709"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100060509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100060509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T11:10:16Z","timestamp":1697886616000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100060509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1988,9]]}},"alternative-id":["10.1002\/jor.1100060509"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100060509","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,9]]},"assertion":[{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}