{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T04:10:50Z","timestamp":1784607050891,"version":"3.55.0"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":5833,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1989,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two normal proximal femoral growth plates and core biopsies from six patients with slipped capital femoral epiphysis (SCFE) were studied by electron microscopy. In these SCFE patients, chondrocytes from all the zones of the plate were frequently smaller than normal, more irregular in shape, and many of them were degenerating, with formation of matrix vesicles and cellular debris. Floccular electron\u2010dense material, most likely abnormal proteoglycan, was present in the hypertrophic rough\u2010surfaced endoplasmic reticulum and Golgi apparatus as well as in the extracellular matrix, intermingled with collagen fibrils thinner than normal and lossely arranged. Mineralization of the abnormal matrix of the longitudinal septa of the degenerating zone was either scanty or absent, with scanty formation of irregular and thin bone trabeculae. The\u2010abnormalities observed in SCFE seem to be caused by a change in chondrocyte metabolism with consequent altered synthesis and\/or extracellular aggregation of both collagen and proteoglycan, and scanty mineralization of the abnormal cartilage matrix.<\/jats:p>","DOI":"10.1002\/jor.1100070213","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:53:54Z","timestamp":1109249634000},"page":"252-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["An ultrastructural study of slipped capital femoral epiphysis: Pathogenetic considerations"],"prefix":"10.1002","volume":"7","author":[{"given":"E.","family":"Ippolito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bellocci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Farsetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tudisco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Perugia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-198501000-00008"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-198501000-00009"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-197658040-00005","article-title":"Biochemical abnormalities in patients with slipped capital femoral epiphysis and chondrolysis","volume":"58","author":"Eisenstein A","year":"1976","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1302\/0301-620X.32B1.5","article-title":"The endocrine basis for slipping of the upper femoral epiphysis. An experimental study","volume":"32","author":"Harris WR","year":"1950","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.2106\/00004623-198163070-00007","article-title":"A histochemical study of slipped capital femoral epiphysis","volume":"63","author":"Ippolito E","year":"1981","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_7_2","first-page":"766","volume-title":"Pediatric Orthopedics","author":"McEwen D","year":"1978"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.2106\/00004623-197759080-00013","article-title":"The ultrastructure of the growth plate in slipped capital femoral epiphysis","volume":"59","author":"Mickelson MR","year":"1977","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_9_2","first-page":"463","volume-title":"Pediatric Orthopaedics","author":"Tachdjian MO","year":"1972"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00003086-198209000-00035","article-title":"A review of the primary mechanism of endochondral calcification with special emphasis on the role of cells, mitochondria and matrix vesicles","volume":"169","author":"Wuthier RE","year":"1982","journal-title":"Clin Orthop"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100070213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100070213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T06:50:17Z","timestamp":1697957417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100070213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1989,3]]}},"alternative-id":["10.1002\/jor.1100070213"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100070213","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3]]},"assertion":[{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}