{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:03:06Z","timestamp":1792674186567,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":5284,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral nerves are often mechanically stretched in association with trauma to extremities, resulting in varying degrees of impairment of nerve function. However, little is known about the biomechanical properties of peripheral nerves and limits of stretching that the nerve may undergo before structural changes occur. Also, the injury pattern of nerves under stretching is poorly understood. In the present study, fresh rabbit tibial nerves (<jats:italic>n<\/jats:italic> = 18) were harvested. Nine nerves were stretched to failure in an INSTRON materials testing machine at a rate of 1 cm\/min (strain rate of 0.5%\/s). Loaddeformation and stress\u2010strain curves were determined. Histological examination by light microscopy of the stretched nerves as well as six normal control nerves and three clamped nonstretched control nerves was performed. The results show that the rabbit tibial nerves have an in situ strain of 11.0 + 1.5% and exhibit a nonlinear stress\u2010strain relationship. After 20% strain, the curve becomes linear up to failure. The ultimate strain and tensile strength of the nerves were 38.5 + 2.0% and 11.7 + 0.7 MPa, respectively. At failure, the load dropped suddenly, but the specimens remained grossly intact. Histological analysis of the stretched nerves showed multiple ruptures of perineurial sheaths when compared to controls.<\/jats:p>","DOI":"10.1002\/jor.1100080511","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:45:30Z","timestamp":1109249130000},"page":"694-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":180,"title":["An in vitro mechanical and histological study of acute stretching on rabbit tibial nerve"],"prefix":"10.1002","volume":"8","author":[{"given":"Bj\u00f6rn L.","family":"Rydevik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael K.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Myers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin J.","family":"Triggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Savio L\u2010Y.","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Garfin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(84)90009-5"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(86)90023-3"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1945.02300080044005"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.52B2.354"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18003012012"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1956.13.1.0043"},{"key":"e_1_2_1_8_2","first-page":"348","article-title":"Biomechanical and histological assessment of human lumbosacral spinal nerve roots","volume":"14","author":"Kwan MK","year":"1989","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_9_2","first-page":"109","article-title":"Analysis of rabbit peripheral nerve: in situ stresses and strains","volume":"98","author":"Kwan MK","year":"1989","journal-title":"Biom Symp ASME\/AMD"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197557070-00011"},{"key":"e_1_2_1_11_2","volume-title":"Nerve Injury and Repair","author":"Lundborg G","year":"1988"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1973.tb01301.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1302\/0301-620X.55B2.390","article-title":"Effects of stretching the tibial nerve of the rabbit: a preliminary study of the intraneural circulation and the barrier function of the perineurium","volume":"5","author":"Lundborg G","year":"1973","journal-title":"J Bone Joint Surg[Br]"},{"key":"e_1_2_1_14_2","unstructured":"LundborgG RydevikB ManthropeM VaronS LewisJ: Peripheral nerve: the physiology of injury and repair. 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