{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T21:12:46Z","timestamp":1792876366636,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":5042,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1991,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ibuprofen is a widely used cyclo\u2010oxygenase inhibitor in clinical practice. It has been demonstrated by others to have an inhibitory effect on fracture repair in animals. In the present study, we were unable to demonstrate any significant alterations in fracture biomechanics as measured by torsion testing and fracture stage in mature Sprague\u2010Dawley rats treated with 30 mg\/kg\/day oral dose of ibuprofen, starting 3 days following fracture, over a 12\u2010week time interval. Fracture histology and serum osteocalcin levels were no different in treated animals than control animals. Furthermore, histomorphometric parameters of bone remodeling, including bone volume and bone formation rate in the intact tail vertebrae of these animals with unilateral femur fractures, were no different between treated and control animals.<\/jats:p>","DOI":"10.1002\/jor.1100090310","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T11:59:35Z","timestamp":1109246375000},"page":"383-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":168,"title":["The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats"],"prefix":"10.1002","volume":"9","author":[{"given":"Michael H.","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy W.","family":"Troiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Pelker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren M.","family":"Gundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary E.","family":"Friedlaender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040106"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678008990848"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1302\/0301-620X.63B2.7217139","article-title":"Release of prostaglandins from bone and muscle after tibial fractures","volume":"63","author":"Dekel S","year":"1981","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650030111"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197509000-00030"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00003086-198812000-00033","article-title":"Fracture healing and osteocalcin metabolism in vitamin K deficiency","volume":"237","author":"Einhorn TA","year":"1988","journal-title":"Clin Orthop"},{"key":"e_1_2_1_8_2","first-page":"208","volume-title":"Skeletal Physiology and Bone Remodeling in Fundamental and Clinical Bone Physiology","author":"Frost HM","year":"1980"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040508"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040212"},{"key":"e_1_2_1_11_2","unstructured":"HealyJH JuhnA LaneJM BakeC MohlerDG: Prostaglandin E2 enhanced bone formation [Abstract].Am J Bone Min Res1988"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02554834"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-91-6-877"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678709146360"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02556694"},{"key":"e_1_2_1_16_2","first-page":"267","article-title":"Osteocalcin: Biochemical considerations and clinical applications","volume":"226","author":"Lian JB","year":"1988","journal-title":"Clin Orthop"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198307073090107"},{"key":"e_1_2_1_18_2","first-page":"286","volume-title":"Bone and Mineral Research. 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