{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T14:32:33Z","timestamp":1700404353875},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4858,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1991,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An in vitro canine tibia model was used to assess the effects of 48 h of hypothermic (4\u00b0C) ischemia on bone vascular resistance and on responsiveness of intraosseous blood vessels to circulating norepinephrine. Three groups of bones were studied: Group I (<jats:italic>n<\/jats:italic> = 11), 48 h hypothermic ischemia; Group II (<jats:italic>n<\/jats:italic> = 11), 48 h hypothermic ischemia with pretreatment with allopurinol and oxypurinol; and Group III (<jats:italic>n<\/jats:italic> = 10), no ischemia. Resting vascular resistance in both ischemic groups (79 and 74 mmHg\/ml\/min) was significantly higher (<jats:italic>p<\/jats:italic> &lt; 0.0001) than in the nonischemic group (22 mmHg\/ml\/min). Effects of norepinephrine on vascular resistance were significantly greater in both ischemic groups (<jats:italic>p<\/jats:italic> &lt; 0.004). In all three groups, acetylcholine infusion attenuated the increases in perfusion pressure caused by norepinephrine. This demonstrates secretion of endothelial\u2010mediated relaxing factors (EDRF) and prostaglandin for up to 48 h of hypothermic ischemia. As no significant differences were detected between the two ischemic groups, this study failed to demonstrate any protective effect of xanthine oxidase inhibitors.<\/jats:p>","DOI":"10.1002\/jor.1100090615","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:04:40Z","timestamp":1109246680000},"page":"883-889","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effects of ischemia on long bone vascular resistance"],"prefix":"10.1002","volume":"9","author":[{"given":"Timothy R. C.","family":"Davis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Wood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"2355","article-title":"The alpha\u2010adrenoreceptors on endothelial cells","volume":"45","author":"Angus JA","year":"1986","journal-title":"Fed Proc"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1988.01400290083014"},{"key":"e_1_2_1_4_2","first-page":"66","article-title":"Free radical\u2010mediated reperfusion injury: A selective review","volume":"8","author":"Bulkley GB","year":"1988","journal-title":"Br J Cancer"},{"key":"e_1_2_1_5_2","first-page":"682","article-title":"Enhancement of alpha\u20101 and alpha\u20102 adrenergic agonist\u2010induced vasoconstriction by removal of endothelium in rat aorta","volume":"232","author":"Carrier GO","year":"1985","journal-title":"J Pharmacol Exper Ther"},{"key":"e_1_2_1_6_2","first-page":"197","article-title":"The effect of progressive ischemia on the vascular reactivity of the isolated canine tibia [Abstract]","volume":"11","author":"Clothiaux PL","year":"1986","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_7_2","first-page":"287","article-title":"Effect of antagonist drugs on bone vascular smooth muscle [Abstract]","volume":"15","author":"Dean M","year":"1990","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_8_2","first-page":"H904","article-title":"Vascular reactivity of the isolated tibia of the dog","volume":"236","author":"Driessens M","year":"1979","journal-title":"Am J Physiol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02584533"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106781"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/288373a0"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198402000-00023"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0022-5223(19)35755-1","article-title":"Oxygen\u2010derived free radical scavengers for amelioration of reperfusion damage in heart transplantation","volume":"95","author":"Jurmann MJ","year":"1988","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_1_14_2","first-page":"8","article-title":"Experimental osteonecrosis of the femoral head of adult rabbits","volume":"130","author":"Kenzora JE","year":"1978","journal-title":"Clin Orthop"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198307000-00017"},{"key":"e_1_2_1_16_2","first-page":"256","article-title":"The no\u2010reflow phenomenon in experimental free flaps","volume":"61","author":"May JW","year":"1978","journal-title":"Plast Micro Surg"},{"key":"e_1_2_1_17_2","first-page":"685","volume-title":"Physicians' Desk Reference","year":"1986"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198502000-00016"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015728"},{"key":"e_1_2_1_20_2","first-page":"418","article-title":"The effects of progressive normothermic and hypothermic ischemia on bone vascular smooth muscle: An ex\u2010vivo study [Abstract]","volume":"14","author":"Settergren CR","year":"1989","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112793"},{"key":"e_1_2_1_22_2","first-page":"67","volume-title":"Vasodilatation","author":"Vanhoutte PM","year":"1981"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198808253190809"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-198809000-00021"},{"key":"e_1_2_1_25_2","first-page":"327","article-title":"Ischemia of the skin","volume":"56","author":"Willms\u2010Kretshmer K","year":"1969","journal-title":"Am J Path"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100090615","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100090615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T17:00:43Z","timestamp":1695834043000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100090615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,11]]}},"alternative-id":["10.1002\/jor.1100090615"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100090615","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11]]},"assertion":[{"value":"1990-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1990-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}