{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:49:07Z","timestamp":1791139747558,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4676,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have developed a new delivery system for sustained release of an anticancer drug (<jats:italic>cis<\/jats:italic>\u2010platinum) by enclosure into blocks of porous calcium hydroxyapatite ceramic. The slow release of this drug from this system was confirmed in in vitro experiments. When this system was implanted into normal back muscle, or the tibia, sustained release of <jats:italic>cis<\/jats:italic>\u2010platinum was observed during a 12\u2010week period after implantation. The diffusion rate of <jats:italic>cis<\/jats:italic>\u2010platinum into blood and other organs (liver, kidney, brain) was less than 10% of that at the implanted site. This delivery system placed into experimental tumors of mice also showed a uniform release of anticancer drug for more than 3 months. Inhibition of tumor growth was more marked after local implantation of this system than after intraperitoneal administration of <jats:italic>cis<\/jats:italic>\u2010platinum. These results indicate that this new approach to a drug delivery system may well have an important role in cancer chemotherapy. In bone tumors it is attractive because the mechanical strength of calcium hydroxyapatite ceramic permits partial surgical excision and replacement of the bone defect at the same time.<\/jats:p>","DOI":"10.1002\/jor.1100100317","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:31:15Z","timestamp":1109248275000},"page":"440-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":130,"title":["Slow release of anticancer drugs from porous calcium hydroxyapatite ceramic"],"prefix":"10.1002","volume":"10","author":[{"given":"A.","family":"Uchida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Shinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.1987.tb04842.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.18.7029"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800701)46:1<14::AID-CNCR2820460103>3.0.CO;2-N"},{"key":"e_1_2_1_5_2","first-page":"3935","article-title":"Multivesicular liposomes containing 1\u2010\u03b2\u2010D\u2010arabinofuranosylcytosine for slow\u2010release intrathecal therapy","volume":"47","author":"Kim S","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(81)90059-4"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.820221205"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0192-0561(85)90062-1"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1093\/clinchem\/23.7.1245","article-title":"Analysis for platinum in biological material by flameless atomic absorption spectrometry","volume":"23","author":"Pera MF","year":"1977","journal-title":"Clin Chem"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(84)90113-5"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(84)90009-7"},{"key":"e_1_2_1_12_2","first-page":"626","article-title":"A sustained release anticancer device","volume":"33","author":"Sugitachi A","year":"1987","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100030108"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198466020-00014"},{"key":"e_1_2_1_15_2","first-page":"3231","article-title":"Development of a slow release system of anticancer drug retained in calcium hydroxyapatite ceramic","volume":"16","author":"Uchida A","year":"1989","journal-title":"Jpn J Cancer Chemother"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100100317","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100100317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T12:39:46Z","timestamp":1698151186000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100100317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1002\/jor.1100100317"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100100317","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]},"assertion":[{"value":"1990-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1991-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}