{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T09:16:46Z","timestamp":1769764606453,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4553,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1992,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluates the effect of crushing load on functional recovery of the sciatic nerve. Male Sprague\u2010Dawley rats were divided into five groups: sham operation, resected sciatic nerve, and 100 g (13 mm Hg\/mm<jats:sup>2<\/jats:sup>), 500 g (50 mm Hg\/mm<jats:sup>2<\/jats:sup>), and 15,000 g (1,000 mm Hg\/mm<jats:sup>2<\/jats:sup>) of sciatic crush load (groups 1\u20135). In groups 3\u20135, a 5\u2010mm segment of sciatic nerve was crushed for 10 min using a specially designed crushing device. Motor functional recovery was assessed from hind\u2010limb walking tracks by calculating a sciatic functional index. There was no detectable functional deficit in the group receiving sham operations, while the resected sciatic nerve group exhibited complete dysfunction for the full duration of the experiment. All groups subjected to crush exhibited an initial deficit that gradually recovered to normal by day 14 (100\u2010g crush), day 39 (500\u2010g crush), and day 53 (15,000\u2010g crush). Histological changes were also related to the initial crushing load and the length of the recovery period. Results indicate that the crushing device described is able to administer an adjustable, defined crush injury to the rat sciatic nerve, and that the functional deficit resulting from such an injury can be easily monitored with a sciatic functional index. The rate of recovery of crushed nerves was directly related to the initial load. All crushed nerves recovered in this experiment, even after the application of a 15,000\u2010g load for 10 min.<\/jats:p>","DOI":"10.1002\/jor.1100100508","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:17:27Z","timestamp":1109247447000},"page":"657-664","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["The functional recovery of peripheral nerves following defined acute crush injuries"],"prefix":"10.1002","volume":"10","author":[{"given":"Long\u2010En","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony V.","family":"Seaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard R.","family":"Glisson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Davies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A. 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