{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:46:34Z","timestamp":1787895994545,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Several methods have been employed in the study of bone perfusion. We used a method of determining inert gas wash\u2010out by mass spectrometry in the study of blood flow rates in pigs. The method was validated by comparison of the result obtained with inert gas wash\u2010out to that with measurement by microspheres. Furthermore, the effect of decreased inlet flow and venous congestion on the bone perfusion data was tested. The undisturbed bone blood flow was not significantly different when measured with wash\u2010out of inert gas (7 \u00b1 0.7 ml\/min\/100 g) or with microspheres (9 \u00b1 2.9 ml\/min\/100 g), and the methods were correlated. Perfusion was reduced significantly, to 20% of the original value, after arterial occlusion. The changes in wash\u2010out curves and accumulation of radioactive tracer provided substantial evidence for impaired intraosseous circulation following venous obstruction also. In conclusion, the study showed that this method of determining inert gas wash\u2010out is feasible for studies of local perfusion rates in bone. The flow rates obtained by wash\u2010out correlated well with the results of microsphere studies. In this animal model, both methods detected a fivefold reduction in flow rate after clamping of the arterial inflow. Obstruction of the venous outflow also impaired blood flow and lowered the cellular supply.<\/jats:p>","DOI":"10.1002\/jor.1100110105","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T07:19:14Z","timestamp":1109229554000},"page":"28-35","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The relationship between inert gas wash\u2010out and radioactive tracer microspheres in measurement of bone blood flow: Effect of decreased arterial supply and venous congestion on bone blood flow in an animal model"],"prefix":"10.1002","volume":"11","author":[{"given":"Thomas","family":"Ki\u00e6r","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benny","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar Schwarz","family":"Lausten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"627","article-title":"Observations on the reaction of tubular bone to venous stasis","volume":"100","author":"Abdalla ABE","year":"1966","journal-title":"J Anat"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1302\/0301-620X.54B3.409","article-title":"Venous engorgement and intraosseous hypertension in osteoarthritis of the hip","volume":"54","author":"Arnoldi CC","year":"1972","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00003086-198909000-00028","article-title":"A microangiographic study of idiopathic osteonecrosis of the femoral head","volume":"246","author":"Atsumi T","year":"1989","journal-title":"Clin Orthop"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/000331976401500903"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1302\/0301-620X.50B3.493","article-title":"Primary osteoarthritis, venous engorgement and osteogenesis","volume":"50","author":"Brookes M","year":"1968","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_7_2","volume-title":"The Blood Supply of Bone","author":"Brookes M","year":"1971"},{"key":"e_1_2_1_8_2","first-page":"873","article-title":"Bone blood pH and gas tensions after femoral vein ligation","volume":"135","author":"Brookes M","year":"1972","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1971.31.4.598"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/00003086-198603000-00032","article-title":"Microcirculation of the juvenile knee in chronic arthritis","volume":"204","author":"B\u00fcnger C","year":"1986","journal-title":"Clin Orthop"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.16.5.461"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1962.sp006909"},{"key":"e_1_2_1_13_2","first-page":"201","article-title":"Effect of exposure to compressed air and elevated oxygen levels on bone blood flow in the rabbit","volume":"17","author":"Davis TRC","year":"1990","journal-title":"Undersea Biomed Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.67B1.3155745"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1152\/jappl.1989.66.4.1942","article-title":"Estimation of blood flow distribution in skeletal muscle from inert gas washout","volume":"66","author":"Gr\u00f8nlund J","year":"1989","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1979.237.4.H440"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(61)91138-2"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1988.tb08342.x"},{"key":"e_1_2_1_19_2","first-page":"447","article-title":"Quantification of bone blood flow in dogs","volume":"16","author":"Kane WJ","year":"1965","journal-title":"Surg Forum"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.2106\/00004623-196850040-00015","article-title":"Anatomy, physiology, and pathology of the blood supply of bones","volume":"50","author":"Kelly PJ","year":"1968","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_21_2","first-page":"1","article-title":"The theory and applications of the exchange of inert gas at the lungs and tissues","volume":"3","author":"Kety SS","year":"1951","journal-title":"Pharmacol Rev"},{"key":"e_1_2_1_22_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00003086-198804000-00019","article-title":"Subchondral pO2, pCO2, pressure, pH, and lactate in human osteoarthritis of the hip","volume":"229","author":"Ki\u00e6r T","year":"1988","journal-title":"Clin Orthop"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.0954-6820.1967.tb12621.x","article-title":"On the theory of the local clearance method for measurement of blood flow including a discussion of its application to various tissues","volume":"472","author":"Lassen NA","year":"1967","journal-title":"Acta Med Scand Suppl"},{"key":"e_1_2_1_24_2","volume-title":"Tracer Kinetic Methods in Medical Physiology","author":"Lassen N","year":"1981"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100070109"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1980.48.2.376"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02408523"},{"key":"e_1_2_1_28_2","first-page":"311","article-title":"Observations on the intramedullary blood\u2010flow and marrow\u2010pressure in bone","volume":"24","author":"Shaw NE","year":"1963","journal-title":"Clin Sci"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-49802-2_21"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.2106\/00004623-196749040-00011","article-title":"An indirect method of bone blood\u2010flow measurement based on the bone clearance of a circulating bone\u2010seeking radioisotope","volume":"49","author":"Shim SS","year":"1967","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_31_2","first-page":"353","article-title":"The relationship between blood flow and marrow cavity pressure of bone","volume":"135","author":"Shim S\u2010S","year":"1972","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1302\/0301-620X.72B3.2341434","article-title":"The role of the tibial nutrient artery: microsphere estimation of blood flow in the osteotomised canine tibia","volume":"72","author":"Strachan RK","year":"1990","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678208992171"},{"key":"e_1_2_1_34_2","first-page":"25","article-title":"Haemodynamics of long bones: an experimental study in dogs","volume":"205","author":"T\u00f8ndevold E","year":"1983","journal-title":"Acta Orthop Scand Suppl"},{"key":"e_1_2_1_35_2","first-page":"353","article-title":"Regional cerebral blood flow determination by 133Xe inhalation and external recording: the effect of arterial recirculation","volume":"30","author":"Veall N","year":"1966","journal-title":"Clin Sci"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1974.36.5.600"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00003086-198205000-00041","article-title":"The acute effects of blocking medullary blood supply on regional cortical blood flow in canine ribs as measured by the hydrogen washout technique","volume":"165","author":"Weiland AJ","year":"1982","journal-title":"Clin Orthop"},{"key":"e_1_2_1_38_2","first-page":"340","article-title":"Measurement of regional bone and bone marrow blood flow in the rabbit using the hydrogen washout technique","volume":"122","author":"Whiteside LA","year":"1977","journal-title":"Clin Orthop"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100110105","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100110105","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T12:34:01Z","timestamp":1734957241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100110105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/jor.1100110105"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100110105","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]},"assertion":[{"value":"1991-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1992-07-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}