{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:18:48Z","timestamp":1762100328442},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The influence of external load on the blood flow of the rabbit tibia was assessed by laser Doppler flowmetry (LDF). Blood flow readings were obtained from three adolescent and three adult female New Zealand White rabbits whose tibiae previously had been pinned with modified orthopaedic pins. Readings were obtained from the exposed mid\u2010shaft of the tibia of each hind leg before, during, and after loading. The loading was either static or sinusoidal intermittent. The LDF resulted in a reading from the tibia which was consistent with the recordings of blood flow; the traces were similar to the pulsatile nature of pulse pressure recordings. After loading of the tibia, in both the adolescent and adult rabbits the effects were an increase in blood flow, as measured with LDF, on the tensile aspect, and a decrease in flow on the compressive side. These changes were statistically significant (p &lt; 0.01) as measured by a Student <jats:italic>t<\/jats:italic> test. This change in flow reached a plateau with change in strain. Furthermore, the changes in flow produced by loading continued as long as the load was applied. A response similar to reactive hyperaemia occurred on the compressive aspect of the tibia; there was an increase of blood flow above the resting level after removal of the static load. The effect of a sinusoidal intermittent load was less than that of a static load, and the differences in flow between tensile and compressive aspects was not significant. The changes induced offer further insight into factors controlling bone remodelling.<\/jats:p>","DOI":"10.1002\/jor.1100110106","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:19:14Z","timestamp":1109247554000},"page":"36-48","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Blood flow changes in the tibia during external loading"],"prefix":"10.1002","volume":"11","author":[{"given":"F.","family":"McDonald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. R. 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