{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:00:54Z","timestamp":1790827254817,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Techniques of tissue exclusion have been used previously in qualitative investigations of the vascularity of long bones, after experimental fracture; we quantified their effects on bone blood flow in rabbits. Thirty\u2010six adult rabbits were divided into three groups in which flow was measured, with the microsphere technique, 1 and 2 weeks after osteotomy. In Group 1, osteotomy of the tibial shaft only was done; in Group 2, osteotomy was done with exclusion of the periosteum and muscle by a silicone rubber sheath; and in Group 3, osteotomy was done with exclusion of the marrow by reaming and insertion of an intramedullary nail. All involved limbs were immobilized in a cast. In Group 1, cortical flow increased but marrow flow did not change, which suggests that the changes in cortical flow were mediated by a supply paralleling that of the marrow. In Group 2, the changes in cortical flow were abolished, which implies that this parallel supply is from the periosteum and extraosseous tissues. In Group 3, cortical flow was not significantly reduced, which demonstrates reeruitment of this periosteal and extraosseous supply. These results lend support to the hypothesis that the blood supply to the healing diaphysis is principally from the periosteum and extraosseous tissues during the early peak period of blood flow.<\/jats:p>","DOI":"10.1002\/jor.1100110107","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:19:14Z","timestamp":1109247554000},"page":"49-57","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A quantitative study of the routes of blood flow to the tibial diaphysis after an osteotomy"],"prefix":"10.1002","volume":"11","author":[{"given":"Paul D.","family":"Triffitt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharine A.","family":"Cieslak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Gregg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2106\/00004623-197759030-00015","article-title":"The effect of fixation with intramedullary rods and plates on fracturesite blood flow and bone remodeling in dogs","volume":"59","author":"Barron SE","year":"1977","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_3_2","first-page":"61","article-title":"The vascularization of the rabbit femur and tibiofibula","volume":"91","author":"Brookes M","year":"1957","journal-title":"J Anat"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-73644-5_40"},{"key":"e_1_2_1_5_2","first-page":"731","article-title":"An experimental study of the vascular contribution to the callus of fracture","volume":"120","author":"Cavadias AX","year":"1965","journal-title":"Surg Gynec Obstet"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100040205"},{"key":"e_1_2_1_7_2","article-title":"Reaming of the medullary cavity and its effect on diaphyseal bone","volume":"128","author":"Danckwardt\u2010Lilliestr\u00f6m G","year":"1969","journal-title":"Acta Orthop Scand Suppl"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.2106\/00004623-197052070-00013","article-title":"Intracortial circulation after intramedullary reaming with reduction of pressure in the medullary cavity: a microangiographic study on the rabbit tibia","volume":"52","author":"Danckwardt\u2010Lilliestr\u00f6m G","year":"1970","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_9_2","first-page":"289","article-title":"Arterial changes in experimental fractures of the rabbit's tibia treated with intramedullary nailing: a microangiographic study","volume":"120","author":"G\u00f6thman L","year":"1960","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_10_2","first-page":"56","article-title":"Arterial changes in experimental fractures of the monkey's tibia treated with intramedullary nailing: a microangiographic study","volume":"121","author":"G\u00f6thman L","year":"1961","journal-title":"Acta Chir Scand"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197254050-00005"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1302\/0301-620X.60B4.711811","article-title":"The uptake by the canine tibia of the bone\u2010scanning agent 99mTc\u2010MDP before and after an osteotomy","volume":"60","author":"Hughes S","year":"1978","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197961060-00009"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/00003086-198611000-00004","article-title":"The effects of reaming and intramedullary nailing on fracture healing","volume":"212","author":"Kessler SB","year":"1986","journal-title":"Clin Orthop"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02589734"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2106\/00004623-196951020-00009","article-title":"Blood flow, oxygen consumption, carbon\u2010dioxide production, and blood\u2010calcium and pH changes in tibial fractures in dogs","volume":"51","author":"Laurnen EL","year":"1969","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100070109"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198567050-00011"},{"key":"e_1_2_1_19_2","unstructured":"OniOOA:Delayed union of fractures of the shaft of the adult tibia: a clinical and experimental study. 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