{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T08:54:28Z","timestamp":1774342468909,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Compression of the spinal nerve roots may occur clinically at multiple levels at the same time; however, the basic pathophysiology of multilevel compression is largely unknown. In this study, the intraneural blood flow was analyzed continuously in the uncompressed segment between two compression balloons, with a pig used as an experimental model and a thermal diffusion method. At 10 mm Hg compression, there was a 64% reduction of total blood flow in the uncompressed segment compared with pre\u2010compression values. Total ischemia occurred at pressures 10\u201020 mm Hg below the mean arterial blood pressure. After two\u2010level compression at 200 mm Hg for 10 min, there was a gradual recovery of the intraneural blood flow towards the baseline. Recovery was less rapid and less complete after 2 h of compression. Double\u2010level compression of the cauda equina can thus induce impairment of blood flow, not only at the compression sites, but also in the intermediate nerve segments located between two compression sites, even at very low pressures. These findings may have clinical importance in the understanding of the pathophysiology of multiple\u2010level cauda equina compression.<\/jats:p>","DOI":"10.1002\/jor.1100110112","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:19:14Z","timestamp":1109247554000},"page":"104-109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Double\u2010level cauda equina compression: An experimental study with continuous monitoring of intraneural blood flow in the porcine cauda equina"],"prefix":"10.1002","volume":"11","author":[{"given":"Keisuke","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Olmarker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sten","family":"Holm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard W.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Rydevik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.12.4.513"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199072010-00018"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390170074031"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1952.sp004772"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198906000-00002"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198711000-00016"},{"key":"e_1_2_1_8_2","article-title":"Ischemic nerve injury: Experimental studies on intraneural microvascular pathophysiology and nerve function in a limb subjected to temporary circulatory arrest","volume":"6","author":"Lundborg G","year":"1970","journal-title":"Scand J Plast Reconstr Surg Suppl"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100070607"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002517-199003000-00005"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","unstructured":"OlmarkerK:Spinal nerve root compression. Experimental studies on effects of acute graded compression on nerve root nutrition and function with an in vivo compression model of the procine cauda equina. [Thesis]. Gothenburg 1990","DOI":"10.3109\/17453679109153920"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199101000-00012"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00003086-199206000-00005","article-title":"Single versus double level nerve root compression: an experimental study on the porcine cauda equina with analyses of nerve impulse conduction properties","volume":"279","author":"Olmarker K","year":"1992","journal-title":"Clin Orthop"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163010-00007"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198507000-00004"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00687706"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199201000-00002"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(81)80003-2"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(77)90131-9"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.7.615"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198811000-00013"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.64.1.0064"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100110112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100110112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T23:51:32Z","timestamp":1698191492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100110112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/jor.1100110112"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100110112","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]},"assertion":[{"value":"1991-12-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1992-06-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}