{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:25:25Z","timestamp":1791926725713,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":4188,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The morphology and composition of the intervertebral disc and also of the cartilage end\u2010plate were studied in patients with idiopathic or congenital scoliosis. The cartilage end\u2010plate was investigated because of its function as an epiphyseal plate in humans and the associaition between growth and progression of the scoliotic curve. The proteoglycan and water contents were reduced in both structures in specimens from scoliotic patients, particularly toward the concavity of the curve, compared with autopsy material. The distribution of some collagen types differed in tissue from scoliotic patients and autopsy tissue. Calcification of the cartilage end\u2010plate, and sometimes of the adjacent disc, occurred in all but three scoliotic patients, whereas there was minimal calcification in the autopsy specimens. We suggest that, although these changes are probably a secondary response to altered loading in the scoliotic patients, they may be highly significant to the progression of the scoliotic curve.<\/jats:p>","DOI":"10.1002\/jor.1100110517","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T11:46:37Z","timestamp":1109245597000},"page":"747-757","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["The cartilage end\u2010plate and intervertebral disc in scoliosis: Calcification and other sequelae"],"prefix":"10.1002","volume":"11","author":[{"given":"S.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Menage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Eisenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2090387"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1302\/0301-620X.63B4.6170646","article-title":"Immunofluorescent staining for collagen and proteoglycan in normal and scoliotic intervertebral discs","volume":"63","author":"Beard HK","year":"1981","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198203000-00002"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-195032040-00008"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198403000-00005"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00386554"},{"key":"e_1_2_1_8_2","first-page":"101","volume-title":"Practical Section Cutting and Staining","author":"Clayden EC","year":"1971"},{"key":"e_1_2_1_9_2","first-page":"261","volume-title":"Instructional Course Lectures, The American Academy of Orthopaedic Surgeons","author":"Cobb JR","year":"1948"},{"key":"e_1_2_1_10_2","first-page":"234","article-title":"Skeletal maturity in adolescent idiopathic scoliosis \u2014 a significant factor in its aetiology?","volume":"74","author":"Dhar S","year":"1992","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.286.6365.615"},{"key":"e_1_2_1_12_2","first-page":"58","volume-title":"Scoliosis and Growth","author":"Duval\u2010Beaupere G","year":"1971"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(86)90306-5"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/00003086-199005000-00046","article-title":"The distribution of calcific deposits in intervertebral discs of the lumbosacral spine","volume":"254","author":"Feinberg J","year":"1990","journal-title":"Clin Orthop"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199107000-00013"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.17.6.685"},{"key":"e_1_2_1_17_2","first-page":"17","article-title":"The etiology of idiopathic scoliosis","volume":"126","author":"Harrington PR","year":"1977","journal-title":"Clin Orthop"},{"key":"e_1_2_1_18_2","first-page":"1","volume-title":"Idiopathic scoliosis and the central nervous system: a motor control problem: the Harrington lecture","author":"Herman R","year":"1983"},{"key":"e_1_2_1_19_2","first-page":"138","volume-title":"The Lumbar Spine and Back Pain","author":"Hukins DWL","year":"1987"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090110"},{"key":"e_1_2_1_21_2","first-page":"1","article-title":"The development of spinal deformity in experimental scoliosis","volume":"81","author":"Michelsson J\u2010E","year":"1965","journal-title":"Acta Orthop Scand Suppl"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/03008208909023888"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198305000-00007"},{"key":"e_1_2_1_24_2","first-page":"52","article-title":"Scoliosis: collagen defect in the intervertebral disc","volume":"7","author":"Parsons DB","year":"1982","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_25_2","first-page":"938","article-title":"Glycosaminoglycans of intervertebral discs in idiopathic scoliosis","volume":"82","author":"Pedrini VA","year":"1973","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2106\/00004623-198365060-00014","article-title":"Proteoglycans of human scoliotic intervertebral disc","volume":"65","author":"Pedrini\u2010Mille A","year":"1983","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_27_2","first-page":"268","article-title":"Pathogenesis of scoliosis","volume":"120","author":"Ponseti IV","year":"1976","journal-title":"Clin Orthop"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-198902000-00005"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199109000-00003"},{"key":"e_1_2_1_30_2","first-page":"95","article-title":"Keratan sulphate and the ultrastructure of cornea and cartilage: a \u201cstand\u2010in\u201d for chondroitin sulphate in conditions of oxygen lack?","volume":"158","author":"Scott JE","year":"1988","journal-title":"J Anat"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1302\/0301-620X.64B1.7068715","article-title":"Intervertebral disc calcification syndromes in children","volume":"64","author":"Sonnabend DH","year":"1982","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199104000-00010"},{"key":"e_1_2_1_33_2","first-page":"777","article-title":"An experimental study on the pathology and role of intervertebral discs in the progression and correction of scoliotic deformity","volume":"62","author":"Toyama Y","year":"1988","journal-title":"Nippon Seikeigeku Gakkai Zasshi"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.3233\/BIR-1978-153-409"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(83)90116-2"},{"key":"e_1_2_1_36_2","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1302\/0301-620X.68B5.3782230","article-title":"Vibratory response in idiopathic scoliosis","volume":"68","author":"Wyatt MP","year":"1986","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_37_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/00003086-198005000-00028","article-title":"Association of glycosaminoglycan depletion and degradative enzyme activity in scoliosis","volume":"148","author":"Zaleske DJ","year":"1980","journal-title":"Clin Orthop"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100110517","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100110517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T05:19:36Z","timestamp":1698297576000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100110517"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,9]]}},"alternative-id":["10.1002\/jor.1100110517"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100110517","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,9]]},"assertion":[{"value":"1992-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1993-01-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}