{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T05:02:22Z","timestamp":1766466142691},"reference-count":44,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":3946,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We used a rat femoral diaphyseal defect\/implant model to quantify the ingrowth of bone, cartilage, and fibrous connective tissue in a comparative study of woven sintered titanium fibermetal and porous hydroxyapatite\/tricalcium phosphate ceramic implanted with and without the addition of syngeneic bone marrow cells. The patterns of tissue growth into the implants were analyzed with respect to time, type of implant, and the presence or absence of syngeneic marrow. Significantly more bone was found in ceramic implants than in fibermetal implants, with the addition of syngeneic marrow than without it, and at 4 months than at 2 months. Significantly more bone was found at both time periods in ceramic implants with bone marrow than in any other combination studied. We hypothesize that these findings resulted from interactions between the implanted material and its surroundings, specifically its ability to serve as a substratum for cell attachment, and cells in and around the defect, whether surgically implanted or arising from the soft\u2010tissue bed.<\/jats:p>","DOI":"10.1002\/jor.1100120317","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T12:08:09Z","timestamp":1109246889000},"page":"439-446","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Histomorphometric analysis of the repair of a segmental diaphyseal defect with ceramic and titanium fibermetal implants: Effects of bone marrow"],"prefix":"10.1002","volume":"12","author":[{"given":"David","family":"Wolff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor M.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2106\/00004623-197860010-00005","article-title":"Segmental replacement of long bones in baboons using a fiber titanium implant","volume":"60","author":"Andersson GBJ","year":"1978","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00400909"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678208992227"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00003086-198605000-00045","article-title":"Pulverized bone matrix as an injectable bone graft in rabbit radius defects","volume":"206","author":"Aspenberg P","year":"1986","journal-title":"Clin Orthop"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0142-9612(90)90052-R"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00003086-198007000-00045","article-title":"The optimum pore size for the fixation of porous\u2010surfaced metal implants by the ingrowth of bone","volume":"150","author":"Bobyn JD","year":"1980","journal-title":"Clin Orthop"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1302\/0301-620X.46B1.110","article-title":"Studies in the transplantation of bone. 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