{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:50:27Z","timestamp":1761058227693},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":3397,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Thirteen adult female rabbits underwent unilateral osteotomy of the proximal tibia. In nine animals, 30\u00b0 of valgus angulation was created; in four animals, osteotomy without angulation was performed. After a 12\u2010week survival period, the knee joints were processed for histology by staining with hematoxylin and eosin and safranin O. Additionally, the chondroitin sulphate epitopes 3\u2010B\u20103 (\u2212) and 7\u2010D\u20104 were evaluated immunohistochemically as markers of osteoarthritis. Changes of the articular surface of the tibia were visualized by scanning electron microscopy. Light microscopic evaluation by the Mankin et al. scoring system revealed mild or moderate damage of the cartilage in the lateral compartment of angulated extremities when compared with the control side. Immunohistology with the monoclonal 3\u2010B\u20103 and 7\u2010D\u20104 antibodies showed no increased expression of these epitopes in the lateral compartments of the knee. Scanning electron microscopic evaluation of the tibial surfaces revealed slight surface damage localized to the central, weight\u2010bearing portion of the lateral tibial plateau of angulated extremities. Angulation of 30\u00b0 led to only mild degenerative changes of the cartilage. These results indicate that, in the short term, cartilage has considerable capacity to withstand the effects caused by severe angulation of the limb.<\/jats:p>","DOI":"10.1002\/jor.1100130607","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T11:02:51Z","timestamp":1109242971000},"page":"846-853","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effects of valgus tibial angulation on cartilage degeneration in the rabbit knee"],"prefix":"10.1002","volume":"13","author":[{"given":"Gy\u00f6rgy","family":"Lov\u00e1sz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adolfo","family":"Llin\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Benya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e9la","family":"Bodey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry A.","family":"McKellop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"James V.","family":"Luck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Augusto","family":"Sarmiento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"687","article-title":"Cartilage matrix markers of osteoarthritis in Cynomolgus monkeys","volume":"18","author":"Carlson CS","year":"1993","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bst0180820"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1242\/jcs.97.3.411","article-title":"Modulation of native chondroitin sulphate structure in tissue development and in disease","volume":"97","author":"Caterson B","year":"1990","journal-title":"J Cell Sci"},{"key":"e_1_2_1_5_2","first-page":"251","article-title":"Biochemical characterization of guinea pig cartilage proteoglycans with the onset of \u201cspontaneous\u201d osteoarthritis","volume":"16","author":"Caterson B","year":"1991","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_6_2","first-page":"415","volume-title":"Articular Cartilage and Osteoarthritis","author":"Caterson B","year":"1992"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100090213"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197306000-00036"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100020302"},{"key":"e_1_2_1_10_2","first-page":"119","article-title":"Experimental production of ridges on rabbit articular cartilage: a scanning electron microscope study","volume":"121","author":"Ghadially FN","year":"1976","journal-title":"J Anat"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/08941939109140776"},{"key":"e_1_2_1_12_2","first-page":"505","article-title":"Appearance of novel chodroitin sulphate structures in the articular cartilage from experimental canine osteoarthritis joints","volume":"14","author":"Hardingham TE","year":"1989","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677008991540"},{"key":"e_1_2_1_14_2","first-page":"278","article-title":"Immunolocalization of atypical chondroitin sulfate chains reacting with the 3\u2010B\u20103 monoclonal antibodies following chymopapain\u2010induced injury in the rabbit","volume":"17","author":"Ishiguro N","year":"1992","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_15_2","first-page":"826","article-title":"Osteotomy for osteoarthritis of the knee [abstract]","volume":"40","author":"Jackson JP","year":"1958","journal-title":"J Bone Joint Surg [Br]"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1093\/ajcp\/84.4.476","article-title":"Immunoalkaline phosphatase cytochemistry","volume":"84","author":"Janckila AJ","year":"1985","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_17_2","first-page":"223","article-title":"Multiplane correctional osteotomy of the tibia for diaphyseal malunion","volume":"215","author":"Johnson EE","year":"1988","journal-title":"Clin Orthop"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0030-5898(20)32289-6","article-title":"Management of malunion and nonunion of the tibia","volume":"18","author":"Johnson KD","year":"1987","journal-title":"Orthop Clin North Am"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0232-1513(88)80061-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197203000-00037"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00003086-198809000-00029","article-title":"Degenerative arthritis of the knee secondary to fracture malunion","volume":"234","author":"Kettelkamp DB","year":"1988","journal-title":"Clin Orthop"},{"key":"e_1_2_1_22_2","first-page":"124","article-title":"Results of around knee osteotomies","volume":"1","author":"Lo v\u00e1sz G","year":"1993","journal-title":"Orthopaedics (Int Ed)"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2450795"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678608994409"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-197153030-00009"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.2106\/00004623-199173090-00014","article-title":"The effect of simulated fracture\u2010angulations of the tibia on cartilage pressures in the knee joint","volume":"73","author":"McKellop H","year":"1991","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_27_2","first-page":"331","article-title":"The severity of pathology in articular cartilage and synovium after induction of osteoarthritis by cruciate ligament transection is related to adequacy of hemostasis at surgery","volume":"15","author":"Myers SL","year":"1990","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1040162"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100110302"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005131-199109000-00001"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-197409000-00087"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453677308989085"},{"key":"e_1_2_1_33_2","first-page":"157","article-title":"Valgus high tibial osteotomy: a long\u2010term follow\u2010up study","volume":"268","author":"Rudan JF","year":"1991","journal-title":"Clin Orthop"},{"key":"e_1_2_1_34_2","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.2106\/00004623-198466090-00002","article-title":"Prefabricated functional braces for the treatment of fractures of the tibial diaphysis","volume":"66","author":"Sarmiento A","year":"1984","journal-title":"J Bone Joint Surg [Am]"},{"key":"e_1_2_1_35_2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/00003086-198003000-00053","article-title":"Induction of osteoarthrosis in the rabbit knee joint: histologic changes following meniscectomy and meniscal lesions","volume":"147","author":"Shapiro FD","year":"1980","journal-title":"Clin Orthop"},{"key":"e_1_2_1_36_2","first-page":"277","article-title":"The occurrence of 3\u2010B\u20103(\u2010) and 7\u2010D\u20104 epitopes as markers of arthritis in humans","volume":"17","author":"Slater RR","year":"1992","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_37_2","first-page":"328","article-title":"Canine experimental osteoarthritis: a comparison of the Pond\u2010Nuki and arthrotomy procedures; macroscopic, histochemical and immunolocalization results","volume":"16","author":"Visco DM","year":"1991","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_38_2","first-page":"644","article-title":"Immunohistochemical analysis of proteoglycan changes in canine experimental osteoarthritis","volume":"17","author":"Visco DM","year":"1992","journal-title":"Trans Orthop Res Soc"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.1100080414"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100130607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100130607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:27:59Z","timestamp":1698362879000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100130607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":38,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1002\/jor.1100130607"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100130607","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]},"assertion":[{"value":"1994-06-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}