{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:27:26Z","timestamp":1790940446804,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":3397,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1995,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Details of the cellular and biochemical mechanisms involved in focal destruction of bone at sites of tumor osteolysis are unknown. It has been shown that tumors from sarcoma (2472) cell lines induce focal osteolysis in mice by stimulating formation and activation of osteoclasts. In this report, the influence of 2472 tumors on the skeletons of osteoclast\u2010deficient animals (<jats:italic>op<\/jats:italic>\/<jats:italic>op<\/jats:italic>) was studied. After <jats:italic>op<\/jats:italic>\/<jats:italic>op<\/jats:italic> femora had been inoculated with 2472 cells, tumors developed and focal osteolysis occurred. There were more osteoclasts per histologic section in sham\u2010injected femora (19 \u00b1 5) than in tumor\u2010bearing femora (412 \u00b1 129) (p &lt; 0.05). The size of the osteoclasts also increased from 304 \u00b1 81 \u03bcm<jats:sup>2<\/jats:sup> in sham\u2010injected limbs to 407 \u00b1 62 \u03bcm<jats:sup>2<\/jats:sup> in tumor\u2010bearing limbs (p &lt; 0.001). Conditioned media from 2472 <jats:italic>op<\/jats:italic>\/<jats:italic>op<\/jats:italic> tumor explants contained macrophage colony\u2010stimulating factor. A deficiency of osteoclasts in <jats:italic>op<\/jats:italic>\/<jats:italic>op<\/jats:italic> mice is the result of the absence of this factor; therefore, these data introduce the possibility that macrophage colony\u2010stimulating factor derived from 2472 tumor may be responsible for directing osteoclast\u2010mediated osteolysis at sites of the tumor.<\/jats:p>","DOI":"10.1002\/jor.1100130613","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T11:02:51Z","timestamp":1109242971000},"page":"892-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Tumor osteolysis in osteopetrotic mice"],"prefix":"10.1002","volume":"13","author":[{"given":"Denis R.","family":"Clohisy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M.","family":"Ogilvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret L. R.","family":"Ramnaraine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,2,18]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"493","article-title":"The hematopoietic deficiencies in osteopetrotic (op\/op) mice are not permanent, but progressively correct with age [letter]","volume":"21","author":"Begg SK","year":"1993","journal-title":"Exp Hematol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.1.237"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"15922","DOI":"10.1016\/S0021-9258(18)47677-6","article-title":"1,25\u2010Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation: up\u2010regulation of the mannose receptor","volume":"262","author":"Clohisy DR","year":"1987","journal-title":"J Biol Chem"},{"issue":"1","key":"e_1_2_1_5_2","first-page":"74","article-title":"Localized, tumor\u2010associated osteolysis in mice involves both osteoclast recruitment and osteoclast activation [abstract]","volume":"9","author":"Clohisy DR","year":"1994","journal-title":"J Bone Miner Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-127-5-2592"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.178.5.1733"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041370125"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.269"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jhered.a108657"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198406283102607"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650030616"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V76.7.1308.1308"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1210\/endo.134.4.8137761","article-title":"Granulocyte\u2010macrophage colony\u2010stimulating factor corrects macrophage deficiencies, but not osteopetrosis, in the colony\u2010stimulating factor\u20101 deficient op\/op mouse","volume":"134","author":"Wiktor\u2010Jedrzejczak W","year":"1994","journal-title":"Endocrinology"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjor.1100130613","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jor.1100130613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:26:36Z","timestamp":1698362796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jor.1100130613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,11]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1995,11]]}},"alternative-id":["10.1002\/jor.1100130613"],"URL":"https:\/\/doi.org\/10.1002\/jor.1100130613","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,11]]},"assertion":[{"value":"1995-01-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1995-03-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}