{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T07:33:48Z","timestamp":1791099228020,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,2,18]],"date-time":"2005-02-18T00:00:00Z","timestamp":1108684800000},"content-version":"vor","delay-in-days":3336,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Our goal was to understand developmental determinants of femoral structure during growth and sexual maturation by relating femoral measurements to gender and developmental factors (age, pubertal stage, height, and body mass). The bone mineral content of the femur was measured by dual energy x\u2010ray absorptiometry in 101 healthy Caucasian adolescents and young adults, 9\u201326 years of age. After some simplifying assumptions had been made, cross\u2010sectional geometric properties of the femoral midshaft were estimated. Two geometry\u2010based structural indicators, the section modulus and whole bone strength index, were calculated to assess the structural characteristics of the femur. Femoral strength, as described by these structural indicators, increased dramatically from childhood through young adulthood. Regressions were performed between these femoral measurements and the developmental factors. Our data show that of age, pubertal stage, body mass, and height, body mass is the strongest predictor of femoral cross\u2010sectional properties, and the correlation of body mass with femoral cross\u2010sectional structure is independent of gender. A model including all four developmental factors and gender did not substantially increase the accuracy of predictions compared with the model with body mass alone. In light of previous research, we hypothesize that body mass is an indicator of\n                    <jats:italic>in vivo<\/jats:italic>\n                    loading and that this\n                    <jats:italic>in vivo<\/jats:italic>\n                    loading influences the cross\u2010sectional growth of the long bones.\n                  <\/jats:p>","DOI":"10.1002\/jor.1100140106","type":"journal-article","created":{"date-parts":[[2005,2,24]],"date-time":"2005-02-24T06:04:12Z","timestamp":1109225052000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Determinants of femoral geometry and structure during adolescent growth"],"prefix":"10.1002","volume":"14","author":[{"given":"Marjolein C. 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